General Surgery, Heping Hospital of Changzhi Medical College, Changzhi, China.
Neoplasma. 2018 Nov 15;65(6):855-864. doi: 10.4149/neo_2018_170720N491. Epub 2018 Sep 4.
The aim of this study is to comprehensively evaluate the associations of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer (CRC). We searched the English and Chinese databases and recruited case-control studies based on strict inclusion and exclusion criteria. The statistical analysis was performed by the Comprehensive Meta-analysis 2.0 (CMA 2.0) software and this initially identified 251 studies. We then recruited 10 English studies to this meta-analysis detailed review which includes 9,415 CRC patients and 14,179 healthy controls. Our results demonstrated that IGFBP3 rs2854746 C>G polymorphism increases susceptibility to the CRC (allele model: OR=1.167, 95% CI=1.0951.244, p<0.001 and to the dominant gene model: OR=1.226, 95% CI=1.1131.350, p<0.001); but IGFBP3 rs2854744 A>C has no significant association with the CRC susceptibility (allele model: OR=0.970, 95% CI=0.9321.010, p=0.138; dominant gene model: OR=0.995, 95% CI=0.9361.057, p=0.874). Also, IGF1 rs35767 C>T polymorphism decreases susceptibility to CRC (allele model: OR=0.785, 95% CI=0.7260.850, p<0.001 and also the dominant model: OR=0.730, 95% CI=0.6610.806, p<0.001). However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective.
本研究旨在全面评估 IGFBP3 和 IGF1 多态性与结直肠癌（CRC）易感性的关联。我们检索了英文和中文数据库，并根据严格的纳入和排除标准招募了病例对照研究。统计分析采用综合荟萃分析 2.0（CMA 2.0）软件进行，该软件最初确定了 251 项研究。然后，我们对这项荟萃分析进行了详细审查，共纳入了 10 项英文研究，这些研究共包括 9415 名 CRC 患者和 14179 名健康对照。我们的研究结果表明，IGFBP3 rs2854746 C>G 多态性增加了 CRC 的易感性（等位基因模型：OR=1.167，95%CI=1.0951.244，p<0.001；显性基因模型：OR=1.226，95%CI=1.1131.350，p<0.001）；然而，IGFBP3 rs2854744 A>C 与 CRC 易感性无显著相关性（等位基因模型：OR=0.970，95%CI=0.9321.010，p=0.138；显性基因模型：OR=0.995，95%CI=0.9361.057，p=0.874）。此外，IGF1 rs35767 C>T 多态性降低了 CRC 的易感性（等位基因模型：OR=0.785，95%CI=0.7260.850，p<0.001；显性模型：OR=0.730，95%CI=0.6610.806，p<0.001）。然而，IGFBP3 rs2854746 C>G 被认为是 CRC 的易感多态性，而 IGF1 rs35767 C>T 是 CRC 的保护性多态性。
