School of Pharmacy, Yancheng Teachers' University, Yancheng, Jiangsu, China.
Physical Examination Centre, Xuhui District Central Hospital of Shanghai, Shanghai, China.
Nucleosides Nucleotides Nucleic Acids. 2022;41(9):815-823. doi: 10.1080/15257770.2022.2081703. Epub 2022 May 28.
Insulin-like growth factor 1 (IGF1) plays an important role in the development and growth of colorectal cancer (CRC). Hence, potential functional polymorphisms of the gene may be involved in CRC risk. This study mainly aimed to assess the association of rs35767 polymorphism with CRC risk in the Chinese Han population by a case-control study and a pooled analysis. In a case-control study with 208 CRC patients and 312 healthy individuals, the rs35767 polymorphism was genotyped by DNA sequencing. Furthermore, a pooled analysis of two case-control studies was performed using Stata software. rs35767 polymorphism was significantly associated with CRC risk in both a case-control study (AA vs. GG: OR = 2.26, 95% CI = 1.35-3.80, = 0.003; AA vs. (GG + GA): OR = 2.32, 95% CI = 1.44-3.74, P = 0.001; A vs. G: OR = 1.43, 95% CI = 1.11-1.85, = 0.007) and a pooled analysis [(GA + AA) versus GG: OR = 1.30, 95% CI = 1.03-1.63, = 0.03; A versus G: OR = 1.28, 95% CI = 1.08-1.53, = 0.01]. In addition, the rs35767 polymorphism was also significantly associated with the stage of CRC. CRC patients with the rs35767 A allele were more likely to have a high tumor stage. These findings indicated that rs35767 polymorphism was linked to CRC risk and tumor stage in the Chinese Han population, and might serve as a valuable biomarker.
胰岛素样生长因子 1（IGF1）在结直肠癌（CRC）的发生和发展中起着重要作用。因此，该基因的潜在功能多态性可能与 CRC 风险相关。本研究通过病例对照研究和荟萃分析，主要评估 rs35767 多态性与中国汉族人群 CRC 风险的关系。在一项包含 208 例 CRC 患者和 312 例健康对照的病例对照研究中，采用 DNA 测序法对 rs35767 多态性进行基因分型。此外，采用 Stata 软件对两项病例对照研究进行了荟萃分析。病例对照研究表明，rs35767 多态性与 CRC 风险显著相关（AA 与 GG：OR = 2.26，95%CI = 1.35-3.80，P = 0.003；AA 与（GG + GA）：OR = 2.32，95%CI = 1.44-3.74，P = 0.001；A 与 G：OR = 1.43，95%CI = 1.11-1.85，P = 0.007），荟萃分析结果也表明，rs35767 多态性与 CRC 风险显著相关[（GA + AA）与 GG：OR = 1.30，95%CI = 1.03-1.63，P = 0.03；A 与 G：OR = 1.28，95%CI = 1.08-1.53，P = 0.01]。此外，rs35767 多态性与 CRC 的分期也显著相关。携带 rs35767A 等位基因的 CRC 患者更有可能处于高肿瘤分期。这些发现表明，rs35767 多态性与中国汉族人群 CRC 风险和肿瘤分期相关，可能成为一个有价值的生物标志物。
