Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Department of Pathology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Neoplasma. 2018 Nov 15;65(6):965-971. doi: 10.4149/neo_2018_171209N808. Epub 2018 Sep 4.
This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001-2016. There were 81males (47.7%) and 89 females 89 (52.3%). The median overall follow-up time was three years. The median tumor volume at baseline was 0.5 cm³ (ranging from 0.2 to 1.6 cm³). The therapeutic dose was 35.0 Gy by 99% of dose volume histogram. The survival after single dose stereotactic radiosurgery was 96% in one year, 93% in two years, 84% in five years, 80% in seven years and 52% in eleven years. Secondary enucleation was necessary for 22 patients because of secondary glaucoma complication. The enucleation free interval ranged from one to six years. The survival rates in five year intervals and necessity of secondary enucleation due to complications after single dose stereotactic radiosurgery is comparable to other techniques.
本文介绍了单次立体定向放射外科治疗眼内脉络膜恶性黑色素瘤的长期疗效，并总结了在 170 例斯洛伐克患者中进行的回顾性研究结果。该组患者为 2001 年至 2016 年间治疗的 20 至 92 岁（中位年龄 59 岁）的眼葡萄膜黑色素瘤患者（149 例脉络膜黑色素瘤，21 例睫状体黑色素瘤），其中男性 81 例（47.7%），女性 89 例（52.3%）。中位总随访时间为 3 年。基线时肿瘤体积中位数为 0.5cm³（范围 0.2 至 1.6cm³）。治疗剂量为 35.0Gy，99%的体积接受 99%的处方剂量。单次立体定向放射外科治疗后 1 年的 1 年生存率为 96%，2 年生存率为 93%，5 年生存率为 84%，7 年生存率为 80%，11 年生存率为 52%。因继发性青光眼并发症，有 22 例患者需要进行二次眼球摘除术。眼球摘除的无瘤间期为 1 至 6 年。5 年生存率和因并发症需要二次眼球摘除术的比率与其他技术相当。
