Giannaccare Giuseppe, Bernabei Federico, Angi Martina, Pellegrini Marco, Maestri Antonio, Romano Vito, Scorcia Vincenzo, Rothschild Pierre-Räphael
Department of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Service d'ophtalmologie, Ophtalmopôle de Paris, Hôpital Cochin, AP-HP, F-75014 Paris, France.
Cancers (Basel). 2021 Apr 16;13(8):1933. doi: 10.3390/cancers13081933.
The ocular surface represents a finely regulated system that allows the protection of the eye. It is particularly susceptible to different treatments for intraocular tumours, such as uveal melanoma and conjunctival cancers. Traditionally, the management of ocular tumours depends on the characteristics of the lesion, and is based on a combination of selective surgery, topical chemotherapy, and/or radiotherapy delivered through different mechanisms (e.g., charged-particle radiotherapy or brachytherapy). Possible complications involving the ocular surface range from transient dry eye disease or keratitis up to corneal melting and perforation, which in any case deserve careful evaluation for the risk of permanent sigh-threatening complications. Clinicians involved in the management of these patients must be aware of this risk, in order to reach an early diagnosis and promptly set up an adequate treatment. The present review of the literature will summarize acute and chronic complications affecting the ocular surface following different therapies for the treatment of ocular tumours.
眼表是一个精细调控的系统，可实现对眼睛的保护。它对眼内肿瘤（如葡萄膜黑色素瘤和结膜癌）的不同治疗方法尤为敏感。传统上，眼肿瘤的治疗取决于病变的特征，并基于选择性手术、局部化疗和/或通过不同机制（如带电粒子放疗或近距离放疗）进行的放疗的联合应用。涉及眼表的可能并发症范围从短暂性干眼疾病或角膜炎到角膜溶解和穿孔，无论如何，这些并发症都值得仔细评估其导致永久性视力威胁并发症的风险。参与这些患者管理的临床医生必须意识到这种风险，以便早期诊断并及时制定适当的治疗方案。本综述将总结不同眼肿瘤治疗方法后影响眼表的急性和慢性并发症。
