Ishikawa S, Sperelakis N
Nature. 1987;327(6118):158-60. doi: 10.1038/327158a0.
Two types of histamine receptor, the H1- and H2-receptors, are found not only on vascular smooth muscle cells but on the perivascular autonomic nerve terminals. Activation of the prejunctional histamine receptors modifies transmitter release from the nerve terminals. Recently, histamine was shown to inhibit its own release from depolarized slices of rat cerebral cortex. This phenomenon was found to be mediated by a novel class of histamine receptor, the H3-receptor, that was pharmacologically distinct from the H1- and H2-receptors. Up to now, there has been no indication whether this third class of histamine receptor is present in any tissue other than the brain. We report here that histamine depresses sympathetic neurotransmission in the guinea-pig mesenteric artery by interacting with histamine H3-receptors on the perivascular nerve terminals. The pharmacological properties of these receptors are similar to those reported for the H3-receptors in the brain. Our data provide evidence for the existence of H3-receptors in the autonomic nervous system.
两种组胺受体，即H1受体和H2受体，不仅存在于血管平滑肌细胞上，也存在于血管周围自主神经末梢上。节前组胺受体的激活会改变神经末梢递质的释放。最近发现，组胺可抑制其自身从大鼠大脑皮层去极化切片中的释放。这一现象被发现是由一类新型组胺受体，即H3受体介导的，其药理学特性与H1受体和H2受体不同。到目前为止，尚无迹象表明除大脑外的任何组织中是否存在这第三类组胺受体。我们在此报告，组胺通过与血管周围神经末梢上的组胺H3受体相互作用，抑制豚鼠肠系膜动脉中的交感神经传递。这些受体的药理学特性与大脑中报道的H3受体相似。我们的数据为自主神经系统中存在H3受体提供了证据。
