Glostrup Research Institute, Glostrup Hospital, Faculty of Health Science, University of Copenhagen, Glostrup, Denmark.
Headache. 2011 Jun;51(6):1029-45. doi: 10.1111/j.1526-4610.2011.01929.x.
Migraine is a neurovascular disorder, and although the pathophysiology of migraine has not been fully delineated, much has been learned in the past 50 years. This knowledge has been accompanied by significant advancements in the way migraine is viewed as a disease process and in the development therapeutic options. In this review, we will focus on 4 mediators (nitric oxide, histamine, serotonin, and calcitonin gene-related peptide) which have significantly advanced our understanding of migraine as a disease entity. For each mediator we begin by reviewing the preclinical data linking it to migraine pathophysiology, first focusing on the vascular mechanisms, then the neuronal mechanisms. The preclinical data are then followed by a review of the clinical data which support each mediator's role in migraine and highlights the pharmacological agents which target these mediators for migraine therapy.
偏头痛是一种神经血管性疾病，尽管偏头痛的病理生理学尚未完全阐明，但在过去 50 年中已经有了很多了解。这一认识伴随着对偏头痛作为疾病过程的看法以及治疗选择的发展的重大进展。在这篇综述中，我们将重点介绍 4 种介质（一氧化氮、组胺、血清素和降钙素基因相关肽），它们极大地促进了我们对偏头痛作为一种疾病实体的理解。对于每种介质，我们首先回顾将其与偏头痛病理生理学联系起来的临床前数据，首先关注血管机制，然后是神经元机制。然后，临床前数据接着回顾支持每种介质在偏头痛中作用的临床数据，并强调针对偏头痛治疗的这些介质的药理学制剂。
