Castellanos A M, Glass J P, Yung W K
Neurology. 1987 May;37(5):834-7. doi: 10.1212/wnl.37.5.834.
Eleven patients at M.D. Anderson Hospital were referred for neurologic evaluation after having their internal or external iliac arteries catheterized for the treatment of localized pelvic or lower extremity tumors. Nine patients developed lumbosacral plexopathies and two patients, mononeuropathies. All symptoms occurred within 48 hours of the intra-arterial infusion. All patients received cis-dichlorodiammine-platinum (cisplatin; CDDP) intra-arterially, alone or in combination with other agents. Follow-up examinations revealed that only one patient had made partial recovery from the neurologic dysfunction. Chemotherapy-induced small vessel injury, with subsequent plexus or nerve infarction, appears to be the most likely cause, although a direct neurotoxic effect of CDDP cannot be excluded.
在MD安德森癌症中心，11名患者因治疗局部盆腔或下肢肿瘤而接受髂内或髂外动脉插管后，被转诊进行神经学评估。9名患者发生腰骶丛病变，2名患者发生单神经病。所有症状均在动脉内输注后48小时内出现。所有患者均接受了动脉内顺二氯二氨铂（顺铂；CDDP）治疗，单独使用或与其他药物联合使用。随访检查显示，只有1名患者的神经功能障碍有部分恢复。化疗引起的小血管损伤，随后导致丛或神经梗死，似乎是最可能的原因，尽管不能排除CDDP的直接神经毒性作用。
