Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
J Cell Biochem. 2019 Apr;120(4):5510-5518. doi: 10.1002/jcb.27834. Epub 2018 Oct 18.
Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and overweight. Thus, any variant in energy metabolism-related gene may influence the development of EGJA. In this study, we recruited 720 EGJA cases and 1541 noncancer controls. We selected IGF2BP2 rs4402960 G > T, rs1470579 A > C, IGF1 rs5742612 A > G and IGFBP3 rs3110697 G > A, rs2270628 C > T and rs6953668 G > A loci and assessed the relationship of these polymorphisms with lymph node status and susceptibility of EGJA. We found that IGF2BP2 rs1470579 A > C and IGFBP3 rs6953668 G > A polymorphisms were associated with the decreased risk of EGJA ( IGF2BP2 rs1470579: CC vs AA: adjusted odds ratio [OR] = 0.65, 95% confidence interval [CI] = 0.43-0.98, P = 0.041 and CC vs AA/AC: adjusted OR = 0.62, 95% CI = 0.41-0.93, P = 0.021 and IGFBP3 rs6953668: GA vs GG: adjusted OR = 0.66, 95% CI = 0.47-0.93, P = 0.019 and GA/AA vs GG: adjusted OR = 0.68, 95% CI = 0.48-0.95, P = 0.026). However, we also found that IGF1 rs5742612 A > G polymorphism increased the risk of LNM among patients with EGJA (GG vs AA: adjusted OR = 1.88, 95% CI = 1.02-3.46, P = 0.042 and GG vs AA/AG: adjusted OR = 1.92, 95% CI = 1.06-3.47, P = 0.032). This study suggests that IGF2BP2 rs1470579 A > C and IGFBP3 rs6953668 G > A polymorphisms may decrease genetic susceptibility to EGJA in eastern Chinese Han population. In addition, our findings also indicate that IGF1 rs5742612 A > G polymorphism may increase the susceptibility of LNM among patients with EGJA.
食管胃结合部腺癌（EGJA）可能与肥胖和超重有关。因此，能量代谢相关基因的任何变异都可能影响 EGJA 的发展。在这项研究中，我们招募了 720 例 EGJA 病例和 1541 名非癌症对照。我们选择了 IGF2BP2 rs4402960 G > T、rs1470579 A > C、IGF1 rs5742612 A > G 和 IGFBP3 rs3110697 G > A、rs2270628 C > T 和 rs6953668 G > A 位点，并评估了这些多态性与淋巴结状态和 EGJA 易感性的关系。我们发现，IGF2BP2 rs1470579 A > C 和 IGFBP3 rs6953668 G > A 多态性与 EGJA 风险降低相关（IGF2BP2 rs1470579：CC 与 AA：调整后的优势比 [OR] = 0.65，95%置信区间 [CI] = 0.43-0.98，P = 0.041 和 CC 与 AA/AC：调整后的 OR = 0.62，95%CI = 0.41-0.93，P = 0.021 和 IGFBP3 rs6953668：GA 与 GG：调整后的 OR = 0.66，95%CI = 0.47-0.93，P = 0.019 和 GA/AA 与 GG：调整后的 OR = 0.68，95%CI = 0.48-0.95，P = 0.026）。然而，我们还发现 IGF1 rs5742612 A > G 多态性增加了 EGJA 患者发生 LNM 的风险（GG 与 AA：调整后的 OR = 1.88，95%CI = 1.02-3.46，P = 0.042 和 GG 与 AA/AG：调整后的 OR = 1.92，95%CI = 1.06-3.47，P = 0.032）。这项研究表明，IGF2BP2 rs1470579 A > C 和 IGFBP3 rs6953668 G > A 多态性可能降低中国东部汉族人群对 EGJA 的遗传易感性。此外，我们的研究结果还表明，IGF1 rs5742612 A > G 多态性可能增加 EGJA 患者发生 LNM 的易感性。
