Zhang Guiming, Zhu Yao, Liu Fang, Gu Chengyuan, Chen Haitao, Xu Jianfeng, Ye Dingwei
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China; Department of Urology, The Affiliated Hospital of Qingdao University, Shandong, People's Republic of China.
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Onco Targets Ther. 2015 Dec 22;9:61-6. doi: 10.2147/OTT.S96294. eCollection 2016.
Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association.
Herein, we examined the association between genetic variants in the IGFBP-3 gene and PCa risk in the Chinese Han population based on a genome-wide association study (1,417 cases and 1,008 controls), and replicated three genetic variants loci in an independent case-control study (1,755 cases and 1,523 controls) using Sequenom platform. Logistic regression analyses were performed to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).
We found that in the discovery stage, rs9691259 (OR =0.691, 95% CI: 0.587-0.814, P<0.001) and rs6950179 (OR =1.420, 95% CI: 1.201-1.677, P<0.001) were significantly associated with PCa risk, whereas rs2854744 showed a marginal association with PCa risk. In the replication stage, the association between rs9691259 and rs6950179 and PCa risk was not replicated, whereas rs2854744 conferred a significant association with PCa risk (OR =1.399, 95% CI: 1.010-1.937, P=0.043). After combining the two stages, we found that rs9691259, rs6950179, and rs2854744 were all significantly associated with PCa risk.
This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population.
越来越多的证据表明，胰岛素样生长因子结合蛋白3（IGFBP-3）基因多态性与前列腺癌（PCa）风险改变相关。然而，在中国人群中进行验证这种关联的研究很少。
在此，我们基于全基因组关联研究（1417例病例和1008例对照），在中国汉族人群中研究了IGFBP-3基因的遗传变异与PCa风险之间的关联，并使用Sequenom平台在一项独立的病例对照研究（1755例病例和1523例对照）中对三个遗传变异位点进行了重复验证。进行逻辑回归分析以估计比值比（OR）和95%置信区间（95%CI）。
我们发现在发现阶段，rs9691259（OR =0.691，95%CI：0.587 - 0.814，P<0.001）和rs6950179（OR =1.420，95%CI：1.201 - 1.677，P<0.001）与PCa风险显著相关，而rs2854744与PCa风险呈边缘关联。在重复验证阶段，rs9691259和rs6950179与PCa风险之间的关联未得到重复验证，而rs2854744与PCa风险存在显著关联（OR =1.399，95%CI：1.010 - 1.937，P =0.043）。将两个阶段的数据合并后，我们发现rs9691259、rs6950179和rs2854744均与PCa风险显著相关。
本研究表明，IGFBP-3基因变异与中国人群的PCa风险显著相关。
