Noguchi K, Kato T, Sunagawa R, Sakanashi M
Pharmacology. 1987;34(1):48-56. doi: 10.1159/000138247.
The regional hemodynamic effects of MC-838, a new angiotensin-converting enzyme inhibitor, and captopril at equidepressor doses were examined in the anesthetized dog by simultaneously measuring renal (RBF), coronary (CBF), vertebral (VBF) arterial and aortic blood flow (AoF). Hemodynamic responses to angiotensin I (AI), AII and noradrenaline were compared before and after the administration of each inhibitor. MC-838 (3 mg/kg i.v.) lowered gradually aortic pressure (AoP) and increased moderately AoF and RBF up to 60 min after the administration. Captopril (0.1 mg/kg i.v.) lowered AoP immediately after the administration and increased AoF and RBF more shortly than MC-838. Neither inhibitor produced a marked change in VBF or CBF. The effects of the inhibitors in the renal vascular bed was much greater than that in vertebral and coronary vascular beds, although vascular resistance in all of them was significantly reduced. Each of the drugs inhibited the pressor and renal vasoconstrictor responses to AI. These results indicate that the renal vasculature is more sensitive to both MC-838 and captopril than vertebral and coronary vasculature, but MC-838 has a slower and longer-lasting action than does captopril.
通过同时测量肾血流量（RBF）、冠状动脉血流量（CBF）、椎动脉血流量（VBF）和主动脉血流量（AoF），在麻醉犬中研究了新型血管紧张素转换酶抑制剂MC - 838和卡托普利在等效降压剂量下的局部血流动力学效应。比较了每种抑制剂给药前后对血管紧张素I（AI）、血管紧张素II（AII）和去甲肾上腺素的血流动力学反应。MC - 838（静脉注射3mg/kg）给药后主动脉压（AoP）逐渐降低，给药后60分钟内主动脉血流量（AoF）和肾血流量（RBF）适度增加。卡托普利（静脉注射0.1mg/kg）给药后立即降低主动脉压，且主动脉血流量（AoF）和肾血流量（RBF）增加的时间比MC - 838更短。两种抑制剂均未使椎动脉血流量（VBF）或冠状动脉血流量（CBF）产生明显变化。尽管所有血管床的血管阻力均显著降低，但抑制剂在肾血管床的作用远大于在椎动脉和冠状动脉血管床的作用。每种药物均抑制了对血管紧张素I的升压和肾血管收缩反应。这些结果表明，肾血管系统对MC - 838和卡托普利的敏感性均高于椎动脉和冠状动脉血管系统，但MC - 838的作用比卡托普利更缓慢且持续时间更长。
