Kato T, Noguchi K, Miyamoto Y, Suekawa M, Aburada M, Hosoya E, Sakanashi M
Arch Int Pharmacodyn Ther. 1987 Feb;285(2):288-300.
The hemodynamic effects of the water extract of flower of Chrysanthemum indicum Linn. (CIL) and adenosine were examined in anesthetized open-chest dogs by measuring simultaneously and continuously coronary (CBF), vertebral (VBF), renal (RBF) and aortic blood flows (AoF). Intravenous administration of CIL (5-20 mg/kg) as well as adenosine (10-50 micrograms/kg) produced decreases in aortic blood pressure (AoP) and RBF, and increases in AoF, VBF, CBF and left ventricular dP/dt (LVdP/dt). Calculated coronary, vertebral and total peripheral resistances were decreased by CIL or adenosine in a dose-dependent manner. The ratio (1.69 +/- 0.27) of decrease in coronary vascular resistance to that in total peripheral resistance by CIL (10 mg/kg) was apparently smaller than that (4.03 +/- 0.48) by adenosine (10 micrograms/kg). After beta-adrenergic blockade, increases in AoF and LVdP/dt were inhibited, but decreases in AoP and coronary, vertebral and total peripheral resistances and increase in renal vascular resistance were not changed. These results indicate that CIL directly and uniformly produces coronary and systemic vasodilation with renal vasoconstriction, and that adenosine directly produces vasoconstriction in renal vasculature and vasodilation which is more potent in coronary vasculature than in systemic ones.
通过同步连续测量冠状动脉血流量（CBF）、椎动脉血流量（VBF）、肾血流量（RBF）和主动脉血流量（AoF），研究了野菊花水提取物（CIL）和腺苷对麻醉开胸犬的血流动力学影响。静脉注射CIL（5 - 20mg/kg）以及腺苷（10 - 50μg/kg）可使主动脉血压（AoP）和RBF降低，使AoF、VBF、CBF和左心室dp/dt（LVdP/dt）增加。CIL或腺苷可使计算得出的冠状动脉、椎动脉和总外周阻力呈剂量依赖性降低。CIL（10mg/kg）使冠状动脉血管阻力降低与总外周阻力降低的比值（1.69±0.27）明显小于腺苷（10μg/kg）的比值（4.03±0.48）。β-肾上腺素能阻断后，AoF和LVdP/dt的增加受到抑制，但AoP降低以及冠状动脉、椎动脉和总外周阻力降低和肾血管阻力增加未改变。这些结果表明，CIL直接且均匀地产生冠状动脉和全身血管舒张并伴有肾血管收缩，而腺苷直接使肾血管产生血管收缩，且在冠状动脉血管中的血管舒张作用比在全身血管中更强。
