2017 年阿斯图里亚斯甲型肝炎流行期间爆发的甲型肝炎导致的急性肝炎。西班牙。
Acute hepatitis due to hepatitis A virus during the 2017 epidemic expansion in Asturias. Spain.
机构信息
Unidad de Hepatología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Servicio de Aparato Digestivo, Hospital Universitario de Cabueñes, Gijón, Asturias, España.
出版信息
Med Clin (Barc). 2019 May 17;152(10):391-394. doi: 10.1016/j.medcli.2018.07.009. Epub 2018 Oct 15.
INTRODUCTION
Since June 2016, there has been an increase in cases of acute hepatitis A (AHA) in several European countries, mainly affecting men who have sex with men (MSM). The aim was to know the characteristics of AHA diagnosed in recent months, comparing them with a previous series.
PATIENTS AND METHODS
All cases of AHA diagnosed in adults between November 2016 and December 2017 (G-I; n=108) were prospectively collected and compared with a series also prospectively collected between January 2004 and September 2016 (G-II; n=49), analysing clinical and epidemiological characteristics.
RESULTS
Compared with group II, in group I there was a greater proportion of males (95.4 vs. 81.6%; p=0.005), of MSM (63.9 vs. 22.4%; p<0.001), of cases with positive luetic serology (20.4 vs 2%; p=0.001) and of severe acute hepatitis (15 vs. 4%; p=0.043).
CONCLUSIONS
AHA diagnosed in recent months in our environment mainly affect MSM and have a more serious presentation with respect to what was observed in a historical series, highlighting the need to increase the vaccination rate against the hepatitis A virus.
介绍
自 2016 年 6 月以来，几个欧洲国家的急性甲型肝炎（AHA）病例有所增加，主要影响男男性行为者（MSM）。目的是了解近几个月诊断出的 AHA 的特征，并将其与之前的系列进行比较。
患者和方法
2016 年 11 月至 2017 年 12 月期间，成人中所有诊断出的 AHA 病例（G-I；n=108）均被前瞻性收集，并与 2004 年 1 月至 2016 年 9 月期间前瞻性收集的另一系列（G-II；n=49）进行比较，分析临床和流行病学特征。
结果
与组 II 相比，组 I 中男性比例更高（95.4% vs. 81.6%；p=0.005），MSM 比例更高（63.9% vs. 22.4%；p<0.001），梅毒血清学阳性的病例比例更高（20.4% vs 2%；p=0.001），重症急性肝炎的比例更高（15% vs. 4%；p=0.043）。
结论
在我们的环境中，最近几个月诊断出的 AHA 主要影响 MSM，其表现比历史系列观察到的更为严重，突出了增加甲型肝炎病毒疫苗接种率的必要性。
Zotero 插件