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1-5 岁从未接种过疫苗的尼日利亚儿童的流行率及相关因素。

Prevalence and correlates of never vaccinated Nigerian children, aged 1-5 years.

机构信息

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Unit 1340, PO Box 301439, Houston, TX 77230-1439, USA.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, 855 N. Wolfe Street, Baltimore, MD 21205, USA.

出版信息

Vaccine. 2018 Nov 12;36(46):6953-6960. doi: 10.1016/j.vaccine.2018.10.006. Epub 2018 Oct 16.

Abstract

INTRODUCTION

A unique population of Nigerian children, aged 1-5 years, never receive any of the recommended childhood vaccines. However, the characteristics of this population has not been previously described. Given Nigeria's historically poor childhood immunization coverage and high child mortality rates, it was imperative we investigate the prevalence and correlates of never-vacccination among Nigerian children.

METHODS

We conducted secondary analysis of the 2013 Nigeria Demographic Health Survey data of Nigerian children, aged 12-59 months (n = 20,586). Weighted multivariate logistic regressions were used to examine the relationship between socio-demographic factors and never-vaccination of Nigerian children. Further regression analysis was conducted after stratifying by Northern and Southern regions.

RESULTS

About twenty one percent of study sample, had never been vaccinated. Over eighty percent of the never-vaccinated children in our study resided in the Northern geopolitical zones of Nigeria. Child never-vaccination was found to be significantly associated with key socio-demographic characteristics. Children born into poor households, with mothers who are unemployed and uneducation, were more likely to be never-vaccinated. Unique predictors of child never-vaccination specific to Northern Nigeria were identified. Islam (aOR: 1.56, 95% CI: 1.11-2.17) and lack of access to Television or Radio (aOR: 1.49, 95% CI: 1.22-1.81) promoted never-vaccination, while increasing maternal age and rural residence (aOR: 0.63, 95% CI: 0.42-0.95) were associated with lower odds of never-vaccination.

CONCLUSION

Socio-demographic factors are predictors of child never-vaccination in Nigeria. Further investigations are needed to better understand the underlying contexts that conribute to child never-vaccination in populations identified in this study. More so, it is important to examine the mechanism through which predictors that are region-speific, culminate in child never-vaccination.

摘要

引言

尼日利亚有一个独特的儿童群体,年龄在 1-5 岁之间,从未接种过任何推荐的儿童疫苗。然而,这个群体的特征以前从未描述过。鉴于尼日利亚儿童免疫接种历史上覆盖率低和儿童死亡率高,我们必须调查尼日利亚儿童从未接种疫苗的流行率及其相关因素。

方法

我们对 2013 年尼日利亚人口与健康调查数据进行了二次分析,研究对象为 12-59 个月大的尼日利亚儿童(n=20586)。采用加权多变量逻辑回归分析方法,研究了社会人口因素与尼日利亚儿童从未接种疫苗之间的关系。在按北部和南部地区分层后,进一步进行了回归分析。

结果

约 21%的研究样本从未接种过疫苗。在我们的研究中,80%以上从未接种过疫苗的儿童居住在尼日利亚北部的地缘政治区。研究发现,儿童从未接种疫苗与关键社会人口特征显著相关。出生在贫困家庭、母亲失业和未受教育的儿童更有可能从未接种过疫苗。还确定了特定于尼日利亚北部地区的儿童从未接种疫苗的独特预测因素。伊斯兰教(aOR:1.56,95%CI:1.11-2.17)和缺乏电视或广播(aOR:1.49,95%CI:1.22-1.81)增加了从未接种疫苗的几率,而增加母亲年龄和农村居住(aOR:0.63,95%CI:0.42-0.95)则与较低的从未接种疫苗几率相关。

结论

社会人口因素是尼日利亚儿童从未接种疫苗的预测因素。需要进一步调查,以更好地了解导致本研究中确定的人群儿童从未接种疫苗的潜在背景。更重要的是,需要研究导致特定于区域的预测因素最终导致儿童从未接种疫苗的机制。

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