Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory, Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
R Samuel McLaughlin Foundation-Exercise and Pregnancy Laboratory, School of Kinesiology, Faculty of Health Sciences, Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Children's Health Research Institute, The University of Western Ontario, London, Ontario, Canada.
Br J Sports Med. 2019 Jan;53(2):116-123. doi: 10.1136/bjsports-2018-099653. Epub 2018 Oct 18.
To investigate the relationships between exercise and incidence of congenital anomalies and hyperthermia.
Systematic review with random-effects meta-analysis .
Online databases were searched from inception up to 6 January 2017.
Studies of all designs were eligible (except case studies and reviews) if they were published in English, Spanish or French, and contained information on population (pregnant women without contraindication to exercise), intervention (subjective or objective measures of frequency, intensity, duration, volume or type of exercise, alone ["exercise-only"] or in combination with other intervention components [e.g., dietary; "exercise + co-intervention"]), comparator (no exercise or different frequency, intensity, duration, volume or type of exercise) and outcome (maternal temperature and fetal anomalies).
This systematic review and meta-analysis included 'very low' quality evidence from 14 studies (n=78 735) reporting on prenatal exercise and the odds of congenital anomalies, and 'very low' to 'low' quality evidence from 15 studies (n=447) reporting on maternal temperature response to prenatal exercise. Prenatal exercise did not increase the odds of congenital anomalies (OR 1.23, 95% CI 0.77 to 1.95, I=0%). A small but significant increase in maternal temperature was observed from pre-exercise to both during and immediately after exercise (during: 0.26°C, 95% CI 0.12 to 0.40, I=70%; following: 0.24°C, 95% CI 0.17 to 0.31, I=47%).
SUMMARY/CONCLUSIONS: These data suggest that moderate-to-vigorous prenatal exercise does not induce hyperthermia or increase the odds of congenital anomalies. However, exercise responses were investigated in most studies after 12 weeks' gestation when the risk of de novo congenital anomalies is negligible.
研究运动与先天性畸形和发热的关系。
系统评价，采用随机效应荟萃分析。
从建库至 2017 年 1 月 6 日，在线数据库进行检索。
所有设计的研究（除病例研究和综述外）都符合条件，研究为英文、西班牙语或法语发表，包含人群（无运动禁忌的孕妇）、干预（运动频率、强度、持续时间、量或类型的主观或客观测量，单独进行[“仅运动”]或与其他干预成分结合[如饮食；“运动+联合干预”]）、对照（不运动或不同的频率、强度、持续时间、量或类型的运动）和结局（母体温度和胎儿畸形）方面的信息。
本系统评价和荟萃分析纳入了 14 项研究（n=78735）的“极低”质量证据，这些研究报告了产前运动与先天性畸形的比值比，纳入了 15 项研究（n=447）的“极低”到“低”质量证据，这些研究报告了产前运动对母体温度的反应。产前运动并未增加先天性畸形的几率（比值比 1.23，95%置信区间 0.77 至 1.95，I=0%）。运动前、运动中和运动后即刻母体温度都出现了较小但有统计学意义的升高（运动中：升高 0.26°C，95%置信区间 0.12 至 0.40，I=70%；运动后即刻：升高 0.24°C，95%置信区间 0.17 至 0.31，I=47%）。
这些数据表明，适度至剧烈的产前运动不会引起发热或增加先天性畸形的几率。然而，大多数研究都是在妊娠 12 周后，即新出现先天性畸形的风险较低时，才对运动反应进行了研究。
