INSERM, UMR1153, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), EArly life Research on later Health Team (EARoH), Villejuif, F-94807, France.
Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Sci Rep. 2018 Oct 18;8(1):15412. doi: 10.1038/s41598-018-33811-2.
The objective was to study the longitudinal associations between inattention/hyperactivity symptoms and night-waking in preschool-years, in light of their joint evolution. Within the French birth-cohort study EDEN, repeated measures of 1342 children's night-waking and inattention/hyperactivity symptoms were collected at age 2, 3 and 5-6 through questionnaires. Trajectories were computed using group-based modeling. Logistic regressions, adjusted for confounding factors, were used to measure the association between trajectories and to determine risk factors for belonging to the identified joint trajectories. Two night-waking trajectories were observed, 20% of the children had a trajectory of "common night-waking", and 80% a trajectory of "rare night-waking". The children were distributed in three inattention/hyperactivity trajectories, a low (47%), medium (40%) and high one (13%). Both night-waking and inattention/hyperactivity trajectories showed persistence of difficulties in preschool years. The risk of presenting a high inattention/hyperactivity trajectory compared to a low one was of 4.19[2.68-6.53] for common night-wakers, compared to rare night-wakers. Factors associated with joint trajectories were parent's education level and history of childhood behavioral problems, and the child's gender, night-sleep duration and collective care at 2 years of age. Results suggest that children presenting behavioral difficulties would benefit from a systematic investigation of their sleep quality and conversely.
目的在于研究学龄前儿童注意缺陷多动障碍症状和夜间觉醒之间的纵向关联，同时考虑它们的共同演变。在法国出生队列研究 EDEN 中，通过问卷在 2 岁、3 岁和 5-6 岁时重复测量了 1342 名儿童的夜间觉醒和注意缺陷多动障碍症状。使用基于群组的建模计算轨迹。使用逻辑回归调整混杂因素，以衡量轨迹之间的关联，并确定属于共同轨迹的风险因素。观察到两种夜间觉醒轨迹，20%的儿童有“常见夜间觉醒”轨迹，80%的儿童有“罕见夜间觉醒”轨迹。儿童分为三种注意缺陷多动障碍轨迹，轻度（47%）、中度（40%）和高度（13%）。夜间觉醒和注意缺陷多动障碍轨迹均显示出学龄前困难持续存在。与罕见夜间觉醒者相比，常见夜间觉醒者中出现高注意缺陷多动障碍轨迹的风险为 4.19[2.68-6.53]。与共同轨迹相关的因素包括父母的教育水平和儿童期行为问题史，以及儿童的性别、夜间睡眠时间和 2 岁时的集体照顾。研究结果表明，有行为困难的儿童将受益于对其睡眠质量进行系统调查，反之亦然。
