Li G, Wang J S, Qin S D, Zhang J, DU N, Zhang J, Sun X, Ren H
Second Department of Thoracic Surgery,First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2018 Oct 18;50(5):840-844.
To study the clinical effect of the oxygen drive aerosol in halation with budesonide and ambroxol in the prevention of adult post-thoracotomy pneumonia.
This was a randomized, open and parallel controlled trial. We chose 80 cases of patients in the department of thoracic surgery in the First Affiliated Hospital of Xi'an Jiaotong University which fitted our criteria as the research object. The selected patients were randomly divided into the active group and the control group, and the active group underwent oxygen drive aerosol inhalation (2 mg budesonide combined 60 mg ambroxol) for 3 days before operation, and the control group without preoperative aerosol inhalation, and their postoperative therapy was the same.
The baseline data showed that the differences in sex, age, disease and smoking were not statistically significant between the two groups, P>0.05. The results of blood gas analysis before 12 hours of operation suggested that, the PaO₂and PaCO₂values of the active group were (88.40±9.40) mmHg and (38.30±6.10) mmHg; The PaO₂and PaCO₂ values of the control group were (85.09±7.18) mmHg and (41.21±3.15) mmHg. And the two groups' P values were 0.029 and 0.011, with statistical differences. There were 3 patients who developed postoperative pneumonia out of 40 patients in the active group, the incidence was 7.50%, but the incidence of control group was 25.00%. The P value was 0.034, with statistical differences. We also analyzed the influence of different diseases and surgical methods on postoperative pneumonia, and the results showed that in the active group and the control group, the incidence of postoperative pneumonia in the patients with esophageal cancer was lower than that in lung cancer patients, and there was a statistically significant difference (P<0.05). In the active group, the numbers of pulmonary deed resection, lobectomy and pulmonary sleeve resection were 2, 21 and 1 cases respectively, and the corresponding numbers in the control group were 2, 21 and 2. Among the two groups, the incidence of postoperative pneumonia in the patients with different surgical methods of lung cancer was statistically significant (P<0.05).
If we implement respiratory preparation with budesonide plus ambroxol inhalation for 3 days before operation, we can greatly reduce the incidence of postoperative pneumonia?
探讨布地奈德联合氨溴索氧驱动雾化吸入预防成人开胸术后肺炎的临床效果。
本研究为随机、开放、平行对照试验。选取西安交通大学第一附属医院胸外科符合标准的80例患者作为研究对象。将入选患者随机分为试验组和对照组，试验组于术前3天给予氧驱动雾化吸入（2 mg布地奈德联合60 mg氨溴索），对照组术前未进行雾化吸入，术后治疗相同。
基线资料显示，两组患者性别、年龄、疾病及吸烟情况差异无统计学意义（P>0.05）。手术前12小时血气分析结果显示，试验组PaO₂和PaCO₂值分别为（88.40±9.40）mmHg和（38.30±6.10）mmHg；对照组PaO₂和PaCO₂值分别为（85.09±7.18）mmHg和（41.21±3.15）mmHg。两组P值分别为0.029和0.011，差异有统计学意义。试验组40例患者中有3例发生术后肺炎，发生率为7.50%，对照组发生率为25.00%。P值为0.034，差异有统计学意义。分析不同疾病及手术方式对术后肺炎的影响，结果显示，试验组和对照组中，食管癌患者术后肺炎发生率低于肺癌患者，差异有统计学意义（P<0.05）。试验组肺楔形切除术、肺叶切除术及肺袖状切除术分别为2例、21例和1例，对照组分别为2例、21例和2例。两组中，肺癌不同手术方式患者术后肺炎发生率差异有统计学意义（P<0.05）。
术前3天应用布地奈德联合氨溴索进行呼吸准备能否大幅降低术后肺炎发生率？
