Department of Oral Medicine, Qilu Hospital of Shandong University, Jinan, China.
Institute of Stomatology, Shandong University, Jinan, China.
Thorac Cancer. 2021 Mar;12(6):768-774. doi: 10.1111/1759-7714.13828. Epub 2021 Jan 24.
Few studies have been conducted on the relationship between chronic periodontitis and postoperative pneumonia (POP) in patients with lung and esophageal cancer. Furthermore, it remains controversial as to whether improving the periodontal condition of patients with lung and esophageal cancer before surgery reduces the incidence of POP. This retrospective study was conducted to assess the effects of periodontal therapy in patients with lung and esophageal cancer to prevent POP.
A total of 265 patients with lung or esophageal cancer complicated with chronic periodontitis who underwent open thoracotomy between July 2015 and June 2019 were selected and given the choice of being in the experimental or control group. A total of 141 participants in the experimental group received periodontal therapy, and 124 participants in the control group did not receive periodontal therapy. All clinical data of participants in both groups were retrospectively studied to determine the incidence of POP on the 30th day after discharge from hospital.
Eight patients in the experimental and six in the control group, respectively, were excluded from the study. It was found that four of the 133 patients suffered from POP in the experimental group (incidence: 3.01%). A total of 18 of 118 patients in the control group had a pulmonary infection (incidence: 15.25%). POP incidence in the experimental group was significantly lower than that in the control group, and in the level analysis of different types of periodontitis, surgical methods, and diseases (p < 0.05).
Periodontal treatment is associated with a lower incidence of POP following lung and esophageal cancer surgery. Improving the periodontal condition of patients helps prevent POP. The presence of periodontitis is an important predisposing factor for POP in patients after open thoracotomy. Periodontal examination and therapy are recommended before the surgical treatment of lung or esophageal cancer.
鲜有研究关注慢性牙周炎与肺癌和食管癌患者术后肺炎（POP）之间的关系。此外，术前改善肺癌和食管癌患者的牙周状况是否能降低 POP 的发生率仍存在争议。本回顾性研究旨在评估牙周治疗对预防 POP 的影响。
选择 2015 年 7 月至 2019 年 6 月期间行开胸手术的 265 例合并慢性牙周炎的肺癌或食管癌患者，并为其提供进入实验组或对照组的选择。实验组共 141 例患者接受牙周治疗，对照组共 124 例患者未接受牙周治疗。对两组患者的所有临床数据进行回顾性研究，以确定出院后 30 天内 POP 的发生率。
实验组和对照组各有 8 例和 6 例患者被排除在研究之外。发现实验组 133 例患者中有 4 例发生 POP（发生率：3.01%）。对照组 118 例患者中共有 18 例发生肺部感染（发生率：15.25%）。实验组的 POP 发生率明显低于对照组，且在不同类型牙周炎、手术方式和疾病的分层分析中（p < 0.05）均存在差异。
牙周治疗与肺癌和食管癌手术后 POP 的发生率较低有关。改善患者的牙周状况有助于预防 POP。开胸术后患者的牙周炎是 POP 的重要诱发因素。建议在肺癌或食管癌的手术治疗前进行牙周检查和治疗。
