Sattari Hossein, Hashemian Morteza, Lashkarizadeh Mohammad Reza, Jalalifard Hamid
Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Iran.
Department of Thoracic surgery, Afzalipoor Hospital, Kerman University of Medical Sciences, Iran.
Open Access Maced J Med Sci. 2018 Sep 18;6(9):1606-1610. doi: 10.3889/oamjms.2018.334. eCollection 2018 Sep 25.
Nowadays pain control is one of the most important challenges for physicians, surgeons and anesthesiologists. New drugs and procedures to control pain have always been a major topic for researches.
In this study, we evaluated the effects of preoperative pregabalin administration on relieving postoperative pain after thoracotomy surgery.
This study is a randomised, double-blind clinical trial, performed on 60 patients who underwent thoracotomy at Afzalipour hospital in Kerman, Iran. They were divided into case and control groups. Two hours before surgery an oral capsule of 300 mg pregabalin or placebo was given to patients. All patients similarly underwent general anaesthesia. Pain, nausea and vomiting were evaluated based on the visual analogue scale (VAS) and frequency. This study was verified and obtained the ethics committee code of K/92/489 from Kerman University of Medical Sciences.
The average age of the pregabalin group was 39.7 ± 5.8 years and the control group 41.3 ± 6.1 years. The average pain score after regaining consciousness was 6.1 ± 0.2 in the case group and 7.9 ± 0.1 in the control group, and there was a significant difference between the 2 groups (p-value = 0.002). In the control group, 2 patients and the intervention group 3 patients, experienced nausea and vomiting. There was a significant difference between the overall average pethidine consumption and the average visual analogue scale in both groups.
Pregabalin administration before thoracotomy is effective to reduce postoperative pain in patients. More research is needed to determine the optimal dose of pregabalin for preoperative administration.
如今，疼痛控制是内科医生、外科医生和麻醉医生面临的最重要挑战之一。控制疼痛的新药和新方法一直是研究的主要课题。
在本研究中，我们评估了术前给予普瑞巴林对开胸手术后缓解术后疼痛的效果。
本研究是一项随机、双盲临床试验，对伊朗克尔曼省阿夫扎利普尔医院60例行开胸手术的患者进行。他们被分为病例组和对照组。手术前两小时给患者口服300毫克普瑞巴林胶囊或安慰剂。所有患者均接受全身麻醉。根据视觉模拟评分法（VAS）和发生频率评估疼痛、恶心和呕吐情况。本研究经克尔曼医科大学验证，并获得伦理委员会代码K/92/489。
普瑞巴林组的平均年龄为39.7±5.8岁，对照组为41.3±6.1岁。病例组清醒后的平均疼痛评分为6.1±0.2，对照组为7.9±0.1，两组间存在显著差异（p值=0.002）。对照组有2例患者、干预组有3例患者出现恶心和呕吐。两组间哌替啶总消耗量的总体平均值与视觉模拟评分平均值存在显著差异。
开胸手术前给予普瑞巴林可有效减轻患者术后疼痛。需要更多研究来确定术前给予普瑞巴林的最佳剂量。
