Singh Tanveer, Kathuria Suneet, Jain Richa, Sood Dinesh, Gupta Shikha
Department of Anaesthesia, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
J Anaesthesiol Clin Pharmacol. 2020 Oct-Dec;36(4):518-523. doi: 10.4103/joacp.JOACP_440_19. Epub 2021 Jan 18.
Pregabalin has been used in various studies for postoperative pain relief in varying doses. However, there is no conclusive evidence to support a safe and effective dose of pregabalin. The present study was designed to compare the efficacy of two different preoperative doses of pregabalin (150 mg and 300mg) in patients undergoing laparoscopic cholecystectomy for postoperative pain relief.
Ninety adult patients of either sex with American Society of Anesthesiologist physical status I and II scheduled for elective laparoscopic cholecystectomy under general anesthesia were randomized to receive pregabalin 150mg (group A), pregabalin 300mg (group B), or placebo (group C) orally 1 h before surgery. The pain was assessed using a visual analog scale (VAS) and a verbal rating scale (VRS) for the initial 24 h postoperatively. The primary outcome of our study was the comparative assessment of the severity of pain in the postoperative period in three groups. Postoperative analgesic consumption and incidence of side effects were assessed as secondary outcome measures.
VAS score was significantly more in group C than group A and B (-value <0.05). The total amount of fentanyl required in 24 h was least in group B (228.33 ± 42.41μg) followed by group A (292.50 ± 46.49μg) and group C (322.50 ± 39.58μg) (-value 0.0001). The incidence of sedation, dizziness, and visual disturbances was more in group B as compared to group A and was least in group C.
Pregabalin 150 mg is effective in decreasing postoperative pain after laparoscopic cholecystectomy with fewer incidences of adverse effects such as sedation and visual disturbances as compared to pregabalin 300 mg.
在各类研究中，已使用不同剂量的普瑞巴林来缓解术后疼痛。然而，尚无确凿证据支持普瑞巴林的安全有效剂量。本研究旨在比较两种不同术前剂量的普瑞巴林（150毫克和300毫克）对接受腹腔镜胆囊切除术患者术后疼痛缓解的疗效。
九十例计划在全身麻醉下接受择期腹腔镜胆囊切除术、美国麻醉医师协会身体状况分级为I级和II级的成年患者，被随机分为三组，分别在手术前1小时口服150毫克普瑞巴林（A组）、300毫克普瑞巴林（B组）或安慰剂（C组）。术后最初24小时使用视觉模拟评分法（VAS）和语言评定量表（VRS）评估疼痛。本研究的主要结局是对三组术后疼痛严重程度的比较评估。术后镇痛药物消耗量和副作用发生率作为次要结局指标进行评估。
C组的VAS评分显著高于A组和B组（P值<0.05）。24小时内所需芬太尼总量最少的是B组（228.33±42.41微克），其次是A组（292.50±46.49微克）和C组（322.50±39.58微克）（P值0.0001）。与A组相比，B组镇静、头晕和视觉障碍的发生率更高，C组最低。
与300毫克普瑞巴林相比，150毫克普瑞巴林在减轻腹腔镜胆囊切除术后疼痛方面有效，且镇静和视觉障碍等不良反应的发生率更低。
