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IllumiScan荧光可视化设备在口腔黏膜病变检测中的临床应用

Clinical Application of the IllumiScan Fluorescence Visualization Device in Detecting Oral Mucosal Lesions.

作者信息

Kikuta Shogo, Iwanaga Joe, Todoroki Keita, Shinozaki Katsumi, Tanoue Ryuichiro, Nakamura Moriyoshi, Kusukawa Jingo

机构信息

Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, JPN.

Medical Education and Simulation, Seattle Science Foundation, Seattle, USA.

出版信息

Cureus. 2018 Aug 6;10(8):e3111. doi: 10.7759/cureus.3111.

DOI:10.7759/cureus.3111
PMID:30338186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6175259/
Abstract

OBJECTIVE

Fluorescence visualization devices are screening devices that can be used to examine lesions of the oral mucosa non-invasively. We observed oral squamous cell carcinoma (OSCC) and leukoplakia using the IllumiScan(Shofu, Kyoto, Japan) fluorescence visualization device and examined its usefulness and characteristics.

METHODS

We investigated 31 OSCC and nine leukoplakia in patients who were examined using the IllumiScan and treated in our department from January 2017 to February 2018. Images taken with the IllumiScan were analyzed using image analysis software. We also examined the lesions using narrowband imaging (NBI). Additionally, the IllumiScan and NBI images and the non-stained areas of iodine staining method (IOM) were visually evaluated.

RESULTS

The average luminance of OSCC in the keratinized mucosa was significantly lower than that of OSCC in non-keratinized mucosa. The average luminance of OSCC was significantly lower than that of leukoplakia. Even in keratinized mucosa where IOM is impossible to use, the OSCC lesion exhibited fluorescence visualization loss.

CONCLUSION

The application of the fluorescence visualization device to the oral mucosa may be useful for distinguishing between cancer and normal areas and can be used to detect OSCC in the keratinized mucosa. The use of the IllumiScan in combination with other conventional screening methods may lead to a better diagnosis.

摘要

目的

荧光可视化设备是一种筛查设备，可用于无创检查口腔黏膜病变。我们使用IllumiScan（日本京都松风公司）荧光可视化设备观察口腔鳞状细胞癌（OSCC）和白斑，并研究其效用和特点。

方法

我们调查了2017年1月至2018年2月期间在我科使用IllumiScan检查并接受治疗的31例OSCC患者和9例白斑患者。使用图像分析软件分析IllumiScan拍摄的图像。我们还使用窄带成像（NBI）检查病变。此外，对IllumiScan和NBI图像以及碘染色法（IOM）的未染色区域进行视觉评估。

结果

角化黏膜中OSCC的平均亮度显著低于非角化黏膜中OSCC的平均亮度。OSCC的平均亮度显著低于白斑的平均亮度。即使在无法使用IOM的角化黏膜中，OSCC病变也表现出荧光可视化缺失。

结论

荧光可视化设备应用于口腔黏膜可能有助于区分癌区和正常区域，并可用于检测角化黏膜中的OSCC。将IllumiScan与其他传统筛查方法联合使用可能会带来更好的诊断效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/f2fc4a25a6fc/cureus-0010-00000003111-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/3b68731d7307/cureus-0010-00000003111-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/84dfba7b47cd/cureus-0010-00000003111-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/ea54a4f4976e/cureus-0010-00000003111-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/0ebc35385679/cureus-0010-00000003111-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/abdd1b01f4b6/cureus-0010-00000003111-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/f2fc4a25a6fc/cureus-0010-00000003111-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/3b68731d7307/cureus-0010-00000003111-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/84dfba7b47cd/cureus-0010-00000003111-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/ea54a4f4976e/cureus-0010-00000003111-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/0ebc35385679/cureus-0010-00000003111-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/abdd1b01f4b6/cureus-0010-00000003111-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da7/6175259/f2fc4a25a6fc/cureus-0010-00000003111-i06.jpg

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