Morikawa Takamichi, Shibahara Takahiko, Nomura Takeshi, Katakura Akira, Takano Masayuki
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Tokyo 102-8159, Japan.
Oral Cancer Center, Tokyo Dental College, Chiba 272-8513; Japan.
Cancers (Basel). 2020 Sep 27;12(10):2771. doi: 10.3390/cancers12102771.
Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations can be repeated using optical instruments. The purpose of this study was to clarify the usefulness of fluorescence visualization in oral cancer screening.
A total of 502 patients, who were examined using fluorescence visualization with optical instruments in our hospitals between 2014 and 2019, were enrolled in this study. The final diagnosis was performed by pathological examination. Fluorescence visualization was analyzed using subjective and objective evaluations.
Subjective evaluations for detecting oral cancer offered 96.8% sensitivity and 48.4% specificity. Regarding the objective evaluations, sensitivity and specificity were 43.7% and 84.6% for mean green value, 55.2% and 67.0% for median green value, 82.0% and 44.2% for coefficient of variation of value, 59.6% and 45.3% for skewness, and 85.1% and 75.8% for value ratio. For the sub-analysis of oral cancer, all factors on objective and subjective evaluation showed no significant difference.
Fluorescence visualization with subjective and objective evaluation is useful for oral cancer screening.
口腔癌筛查对于早期发现和早期治疗至关重要，有助于提高生存率。活检是确诊的金标准，但具有侵入性且会引起疼痛，而荧光可视化是非侵入性的、方便的且实时的，并且可以使用光学仪器重复进行检查。本研究的目的是阐明荧光可视化在口腔癌筛查中的实用性。
本研究纳入了2014年至2019年间在我院使用光学仪器进行荧光可视化检查的502例患者。最终诊断通过病理检查进行。使用主观和客观评估对荧光可视化进行分析。
检测口腔癌的主观评估灵敏度为96.8%，特异度为48.4%。在客观评估方面，平均绿色值的灵敏度和特异度分别为43.7%和84.6%，中位数绿色值为55.2%和67.0%，值的变异系数为82.0%和44.2%，偏度为59.6%和45.3%，值比为85.1%和75.8%。对于口腔癌的亚分析，客观和主观评估的所有因素均无显著差异。
主观和客观评估的荧光可视化对口腔癌筛查有用。
