College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Biomedical Sciences, Shandong Normal University, Jinan 250014, P. R. China.
Chem Commun (Camb). 2018 Nov 14;54(88):12479-12482. doi: 10.1039/c8cc07211f. Epub 2018 Oct 19.
We present a new nanoprobe based on chemiluminescence resonance energy transfer for in vivo imaging of drug-induced alkaline phosphatase (ALP). This probe exhibits the perfect degrees of high sensitivity and specificity for real-time monitoring of ALP levels to directly evaluate drug-induced liver injury.
我们提出了一种基于化学发光共振能量转移的新纳米探针，用于药物诱导的碱性磷酸酶（ALP）的体内成像。该探针具有高度的灵敏度和特异性，可实时监测 ALP 水平，直接评估药物诱导的肝损伤。
