早期炎症和硫酸镁对幼鼠热诱导惊厥的影响：对后期戊四氮诱导惊厥的易感性。
Effect of early-life inflammation and magnesium sulfate on hyperthermia-induced seizures in infant rats: Susceptibility to pentylenetetrazol-induced seizures later in life.
作者信息
Saboory Ehsan, Ghadimkhani Maryam, Roshan-Milani Shiva, Derafshpour Leila, Mohammadi Sedra, Dindarian Sina, Mohammadi Hozan
机构信息
Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
出版信息
Dev Psychobiol. 2019 Jan;61(1):96-106. doi: 10.1002/dev.21781. Epub 2018 Oct 18.
This study investigated the effect of inflammation and MgSO pretreatment on behaviors caused by hyperthermia (HT) and the effect of these interventions on PTZ-induced seizure a week later. In this experimental study, rat pups experienced inflammation on postnatal day 10 (P10). On P18-19, the pups received either saline or MgSO then subjected to hyperthermia. On P25-26, PTZ-induced seizure was initiated in the rats. Neonatal inflammation increased the susceptibility to HT-induced seizure. Inflammation and HT increased the susceptibility to PTZ-induced seizure. Pretreatment with MgSO before hyperthermia decreased the susceptibility to both HT- and PTZ-induced seizure. Furthermore, calcium and magnesium blood levels significantly decreased compared to control rats. It can be concluded that neonatal inflammation potentiates while pretreatment with MgSO attenuates HT-induced seizures. Also, neonatal inflammation and HT potentiate PTZ-induced seizure initiated one week later.
本研究调查了炎症和硫酸镁预处理对高热（HT）所致行为的影响，以及这些干预措施对一周后戊四氮（PTZ）诱导癫痫发作的影响。在这项实验研究中，幼鼠在出生后第10天（P10）经历炎症。在P18 - 19天，幼鼠接受生理盐水或硫酸镁处理，然后进行高热处理。在P25 - 26天，对大鼠诱发PTZ诱导的癫痫发作。新生儿期炎症增加了对HT诱导癫痫发作的易感性。炎症和HT增加了对PTZ诱导癫痫发作的易感性。高热前用硫酸镁预处理降低了对HT和PTZ诱导癫痫发作的易感性。此外，与对照大鼠相比，血液中的钙和镁水平显著降低。可以得出结论，新生儿期炎症会增强高热诱导的癫痫发作，而硫酸镁预处理则会减弱这种发作。此外，新生儿期炎症和HT会增强一周后诱发的PTZ诱导癫痫发作。
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