Freeman Megan Culler, Coyne Carolyn B, Green Michael, Williams John V, Silva Laurie A
Division of Pediatric Infectious Disease, Department of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Pediatr Transplant. 2019 Feb;23(1):e13303. doi: 10.1111/petr.13303. Epub 2018 Oct 19.
Recent years have brought a rise in newly emergent viral infections, primarily in the form of previously known arthropod-transmitted viruses that have increased significantly in both incidence and geographical range. Of particular note are DENV, CHIKV, and ZIKV, which are transmitted mostly by Aedes species of mosquitoes that exhibit a wide and increasing global distribution. Being important pathogens for the general population, these viruses have the potential to be devastating in the international transplant community, with graft rejection and death as possible outcomes of infection. In this review, we discuss the current state of knowledge for these viruses as well as repercussions of infection in the solid organ and HSCT population, with a focus, when possible, on pediatric patients.
近年来，新出现的病毒感染有所增加，主要表现为以前已知的节肢动物传播病毒，其发病率和地理范围都显著增加。特别值得注意的是登革病毒（DENV）、基孔肯雅病毒（CHIKV）和寨卡病毒（ZIKV），它们大多通过伊蚊属蚊子传播，而这些蚊子在全球的分布范围广泛且不断扩大。作为普通人群的重要病原体，这些病毒在国际移植界可能具有毁灭性影响，感染可能导致移植排斥和死亡。在本综述中，我们讨论了这些病毒的现有知识状况以及在实体器官移植和造血干细胞移植人群中感染的影响，如有可能，重点关注儿科患者。
