Transfusion Department, The First Hospital of China Medical University, Shenyang, China.
Eur Rev Med Pharmacol Sci. 2018 Oct;22(19):6386-6395. doi: 10.26355/eurrev_201810_16051.
Breast invasive carcinoma (BRCA) is a complex polygenic disease characterized by molecular and histological heterogeneity. An effort is underway to explore and investigate multiple reliable prognostic markers to improve management of BRCA patients and provide novel therapeutic targets. The aim of the study is to identify the prognostic miRNA signature in BRCA patients.
The miRNA-sequencing data and clinical information of BRCA patients were downloaded from The Cancer Genome Atlas (TCGA) database.
A total of 106 differentially expressed miRNAs were identified between BRCA tissues and matched normal tissues, including 81 up-regulated miRNAs and 25 down-regulated miRNAs. Then, we established a set of three-miRNA signature that was significantly associated with BRCA patients' survival. Using the prognostic three-miRNA signature, we classified the BRCA patients into high-risk and low-risk groups. Multivariate Cox regression demonstrated that the prognostic power of the three-miRNA signature was independent of other clinical variables. Functional enrichment analysis suggested that three prognostic miRNAs may be involved in known BRCA-related KEGG pathways and biological processes.
We demonstrated that three-miRNA signature could be a potential biomarker for predicting clinical outcomes for BRCA patients.
乳腺癌浸润性癌（BRCA）是一种具有分子和组织学异质性的复杂多基因疾病。目前正在努力探索和研究多个可靠的预后标志物，以改善 BRCA 患者的管理，并提供新的治疗靶点。本研究旨在确定 BRCA 患者的预后 miRNA 特征。
从癌症基因组图谱（TCGA）数据库下载 BRCA 患者的 miRNA 测序数据和临床信息。
在 BRCA 组织与匹配的正常组织之间共鉴定出 106 个差异表达的 miRNA，包括 81 个上调的 miRNA 和 25 个下调的 miRNA。然后，我们建立了一组由三个 miRNA 组成的特征，该特征与 BRCA 患者的生存显著相关。使用预后三 miRNA 特征，我们将 BRCA 患者分为高危和低危组。多因素 Cox 回归表明，该三 miRNA 特征的预后能力独立于其他临床变量。功能富集分析表明，三个预后 miRNA 可能参与已知的 BRCA 相关 KEGG 途径和生物学过程。
我们证明，三 miRNA 特征可以作为预测 BRCA 患者临床结局的潜在生物标志物。
