Buzzetti Luca, Crisenza Giacomo E M, Melchiorre Paolo
ICIQ-Institute of Chemical Research of Catalonia the Barcelona Institute of Science and Technology, Avenida Països Catalans 16, 43007, Tarragona, Spain.
ICREA-Catalan Institution for Research and Advanced Studies, Passeig Lluís Companys 23, 08010, Barcelona, Spain.
Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3730-3747. doi: 10.1002/anie.201809984. Epub 2019 Jan 15.
The fast-moving fields of photoredox and photocatalysis have recently provided fresh opportunities to expand the potential of synthetic organic chemistry. Advances in light-mediated processes have mainly been guided so far by empirical findings and the quest for reaction invention. The general perception, however, is that photocatalysis is entering a more mature phase where the combination of experimental and mechanistic studies will play a dominant role in sustaining further innovation. This Review outlines the key mechanistic studies to consider when developing a photochemical process, and the best techniques available for acquiring relevant information. The discussion will use selected case studies to highlight how mechanistic investigations can be instrumental in guiding the invention and development of synthetically useful photocatalytic transformations.
光氧化还原和光催化等快速发展的领域最近为拓展有机合成化学的潜力提供了新的机遇。迄今为止，光介导过程的进展主要由经验性发现和对反应发明的探索所引导。然而，普遍的看法是，光催化正进入一个更加成熟的阶段，在这个阶段，实验研究和机理研究的结合将在维持进一步创新方面发挥主导作用。本综述概述了在开发光化学过程时需要考虑的关键机理研究，以及可用于获取相关信息的最佳技术。讨论将通过选定的案例研究来突出机理研究如何有助于指导合成有用的光催化转化的发明和发展。
