Department of Chemistry, Federal University of Santa Maria, Rio Grande do Sul 97105-900, Brazil.
Department of Chemistry, Federal University of Santa Maria, Rio Grande do Sul 97105-900, Brazil.
Fitoterapia. 2018 Nov;131:80-85. doi: 10.1016/j.fitote.2018.10.013. Epub 2018 Oct 16.
Two new iridoids (1-2) and a new decomposition product of valepotriates (3), together with fifteen known compounds (4-18) were isolated from the roots and rhizomes of Valeriana polystachya Smith, a native species from the Pampa Biome. Their structures were elucidated by means of NMR spectroscopy, mass spectrometry and optical rotation. The structures of 3 and 18 were further confirmed by single crystal X-ray diffraction analysis. In the group of the isolated compounds, 6β-hydroxysitostenone, hydroxymaltol and isovillosol were isolated from the Valeriana genus for the first time. The extracts and isolated compounds were evaluated for their in vitro activities against acetylcholinesterase (AChE) and prolyloligopeptidase (POP). Compounds 7, 9 and 11 showed weak inhibitory activity against AChE, while 3 and 5 displayed exceptional POP inhibitory activity, with IC values of 5.3 ± 0.07 and 7.9 ± 0.4 μM, respectively.
从潘帕斯生物群的本地种植物缬草（Valeriana polystachya Smith）的根和根茎中分离得到了两个新的环烯醚萜（1-2）和一个缬草苦味酯的新分解产物（3），以及十五个已知化合物（4-18）。通过 NMR 光谱、质谱和旋光分析确定了它们的结构。3 和 18 的结构通过单晶 X 射线衍射分析进一步得到了证实。在所分离的化合物中，6β-羟基丁香烯酮、羟麦芽酚和异缬草酸首次从缬草属中分离得到。评估了提取物和分离化合物对乙酰胆碱酯酶（AChE）和脯氨酰寡肽酶（POP）的体外活性。化合物 7、9 和 11 对 AChE 表现出较弱的抑制活性，而 3 和 5 对 POP 表现出异常的抑制活性，IC 值分别为 5.3±0.07 和 7.9±0.4 μM。
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