贾塔瓦勒里德类 A-H，从缬草根和根茎中分离得到的八种新的缬草属环烯醚萜。
Jatavaleridoids A-H, eight new iridoids from the roots and rhizomes of Valeriana jatamansi Jones.
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, PR China.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, PR China.
出版信息
Fitoterapia. 2022 Oct;162:105286. doi: 10.1016/j.fitote.2022.105286. Epub 2022 Aug 25.
Eight new iridoids, jatavaleridoids A-H (1-8), were isolated from the roots and rhizomes of Valeriana jatamansi. Their structures and absolute configurations were elucidated based on NMR and HRESIMS spectroscopic data, as well as quantum chemical calculation. Structurally, compounds 1-5 and 8 were rare iridoids with long-chain fatty acid esters at C-10. In addition, compound 7 showed cytotoxicity, while compounds 1 and 2 exhibited inhibition on NO production.
从缬草（Valeriana jatamansi）的根和根茎中分离得到了 8 个新的环烯醚萜类化合物，分别命名为 jatavaleridoids A-H（1-8）。基于 NMR 和 HRESIMS 光谱数据以及量子化学计算，确定了它们的结构和绝对构型。结构上，化合物 1-5 和 8 是罕见的具有 C-10 长链脂肪酸酯的环烯醚萜类化合物。此外，化合物 7 具有细胞毒性，而化合物 1 和 2 对 NO 生成具有抑制作用。
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