Dil'man V M
Vopr Onkol. 1977;23(6):7-9.
The data obtained previously at our laboratory have evidenced that pineal polypeptide factors enhance the sensitivity of the hypothalamo-hypophyseal complex to the inhibiting action of glucocorticoids and estrogens and show an antistressor effect and the capacity to decrease the level of insulin and triglycerides in the experiment, and also suppress the growth of transplantable mammary gland cancer. In view of this, the pineal polypeptide extract was employed in a patient with reduced indices of cellular immunity. A restoration of indices of blasttransformation reaction induced by phytohemagglutinin, an increased number of rosette-forming cells and an improved response to dinitrochlorobenzene skin test were noted.
我们实验室之前获得的数据表明，松果体多肽因子可增强下丘脑 - 垂体复合体对糖皮质激素和雌激素抑制作用的敏感性，在实验中显示出抗应激作用以及降低胰岛素和甘油三酯水平的能力，还能抑制可移植性乳腺癌的生长。鉴于此，松果体多肽提取物被应用于一名细胞免疫指标降低的患者。结果发现，该患者由植物血凝素诱导的母细胞转化反应指标得到恢复，形成玫瑰花结细胞的数量增加，对二硝基氯苯皮肤试验的反应有所改善。
