内皮型一氧化氮合酶：观点和最新进展。
Endothelial NOS: perspective and recent developments.
机构信息
Vascular Biology and Therapeutics Program, Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Br J Pharmacol. 2019 Jan;176(2):189-196. doi: 10.1111/bph.14522. Epub 2018 Dec 9.
Endothelial NOS (eNOS), and its product NO, are vital components of the control of vasomotor function and cardiovascular homeostasis. In the present review, we will take a deep dive into eNOS enzymology, function and mechanisms regulating endothelial NO. The mechanisms regulating eNOS and NO synthesis discussed here include alterations to transcriptional, post-translational modifications and protein-protein regulations. Also, we will discuss the phenotypes associated with various eNOS mutants and the consequences of a disrupted eNOS/NO cascade, highlighting the importance of eNOS function and vascular homeostasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.
内皮型一氧化氮合酶（eNOS）及其产物一氧化氮（NO）是血管舒缩功能和心血管稳态控制的重要组成部分。在本综述中，我们将深入探讨 eNOS 的酶学、功能和调节内皮 NO 的机制。本文讨论的调节 eNOS 和 NO 合成的机制包括转录、翻译后修饰和蛋白-蛋白调节的改变。此外，我们还将讨论与各种 eNOS 突变体相关的表型以及 eNOS/NO 级联中断的后果，强调 eNOS 功能和血管稳态的重要性。
相关文章
本文是诺贝尔生理学或医学奖 1998 年主题部分的一部分，题为“一氧化氮 20 年”。要查看该部分的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.
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