从 NOS2/COX2 的角度理解肿瘤微环境通讯网络。
Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.
机构信息
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba-ken, Japan.
出版信息
Br J Pharmacol. 2019 Jan;176(2):155-176. doi: 10.1111/bph.14488. Epub 2018 Nov 6.
Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE , respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.
最近的研究结果表明，NOS2 和 COX2 的共表达是三阴性乳腺癌患者的一个强有力的预后指标。这两种关键的炎症相关酶分别负责 NO 和 PGE 的生物合成，并且可以通过自分泌和旁分泌的方式发挥作用。它们的生理调节受损会导致肿瘤内和细胞间与免疫系统的通讯发生关键变化，并使其适应缺氧的肿瘤微环境。最近的研究还确立了 NOS2-COX2 在引起代谢转变中的关键作用。这篇综述提供了一个广泛的概述，介绍了 NO 和 PGE 在塑造由肿瘤和免疫细胞组成的肿瘤微环境之间的通讯中的作用，而这种通讯反过来又有利于肿瘤的进展和转移。相关文章：本文是关于一氧化氮 20 年诺贝尔奖主题部分的一部分。要查看该部分的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.
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