心血管疾病中调节一氧化氮 - 环磷酸鸟苷途径的当代方法
Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease.
作者信息
Kraehling Jan R, Sessa William C
机构信息
From the Vascular Biology and Therapeutics Program (J.R.K.) and Department of Pharmacology (W.C.S.), Yale University, School of Medicine, New Haven, CT.
出版信息
Circ Res. 2017 Mar 31;120(7):1174-1182. doi: 10.1161/CIRCRESAHA.117.303776.
Abstract
Endothelial cells lining the vessel wall control important aspects of vascular homeostasis. In particular, the production of endothelium-derived nitric oxide and activation of soluble guanylate cyclase promotes endothelial quiescence and governs vasomotor function and proportional remodeling of blood vessels. Here, we discuss novel approaches to improve endothelial nitric oxide generation and preserve its bioavailability. We also discuss therapeutic opportunities aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications.
摘要
血管壁内衬的内皮细胞控制着血管稳态的重要方面。特别是，内皮源性一氧化氮的产生和可溶性鸟苷酸环化酶的激活促进内皮细胞的静止，并控制血管舒缩功能和血管的比例重塑。在此，我们讨论改善内皮一氧化氮生成并维持其生物利用度的新方法。我们还讨论了针对多种心血管适应症激活可溶性鸟苷酸环化酶的治疗机会。
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