School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, China.
School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang 212013, Jiangsu, China.
Int J Biol Macromol. 2019 Jan;121:930-935. doi: 10.1016/j.ijbiomac.2018.10.073. Epub 2018 Oct 17.
GP11 had been reported to have effectively anti-tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combination with 5-Fu was investigated in this study. The results demonstrated that such synergism displayed enhance the anti-tumor activity of 5-Fu. Additionally, a strength effect was also observed in regulating immune function of GP11 and 5-Fu simultaneous administration, such as enhancing serum interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) secretion, and increasing immune organs weights. Moreover, GP11 could improve the haematological and biochemical parameters deterioration, superoxide dismutase (SOD) activities reduction and malondialdehyde (MDA) levels enhancement in non-immune organs induced by 5-Fu. All these results illustrated that GP11 exhibited attenuated and synergized effect on 5-Fu by improving the immune function. It could be developed as an auxiliary preparation for chemotherapeutic drugs.
在我们之前的研究中，GP11 通过改善免疫功能被报道具有有效的抗肿瘤活性。为了避免 5-Fu 的缺点，本研究中考察了 GP11 与 5-Fu 的联合应用。结果表明，这种协同作用增强了 5-Fu 的抗肿瘤活性。此外，同时给予 GP11 和 5-Fu 还观察到调节免疫功能的强度效应，例如增强血清白细胞介素-2 (IL-2) 和肿瘤坏死因子-α (TNF-α) 的分泌，以及增加免疫器官的重量。此外，GP11 可以改善由 5-Fu 引起的非免疫器官的血液学和生化参数恶化、超氧化物歧化酶 (SOD) 活性降低和丙二醛 (MDA) 水平升高。所有这些结果表明，GP11 通过改善免疫功能对 5-Fu 表现出减弱和协同作用。它可以开发为化疗药物的辅助制剂。
