School of Chemistry and Chemical Engineering, Jiangsu University, Xuefu Road 301, Zhenjiang 212013, China.
School of Food and Biological Engineering, Jiangsu University, Xuefu Road 301, Zhenjiang 212013, Jiangsu, China.
Int J Biol Macromol. 2014 Feb;63:114-8. doi: 10.1016/j.ijbiomac.2013.10.037. Epub 2013 Nov 2.
Previous study indicated that the refined polysaccharide from Schisandra could improve the CTX-induced inhibition of T and B lymphocytes proliferation. Accordingly, the enhanced antitumor and reduced toxicity effects of a low molecular weight purified polysaccharide from Schisandra (SCPP11) were investigated in 5-fluorouracil (5-Fu) treated Heps-bearing mice. The results revealed that the SCPP11 (oral administration) exhibited a significant enhanced effect of antitumor activity when combined with 5-Fu. Moreover, a increased effect was also observed in boosting immunity functions when the Heps-bearing mice receiving SCPP11 combination with 5-Fu administration, including increased in thymus indexes and enhancing serum IL-2 and TNF-α secretion. In addition, SCPP11 could ameliorate the hematological and biochemical parameters changes induced by 5-Fu to normal level, and reduce the formation of MDA and enhance the activities of SOD in liver to against 5-Fu induced free radical damage. The above results suggested that the SCPP11 combined with 5-Fu presented enhanced effects on antitumor activity and the SCPP11 could attenuate the 5-Fu-induced toxicity effect. It could serve as a new and promising adjuvant for chemotherapy drugs.
先前的研究表明，五味子精制多糖可改善 CTX 对 T 和 B 淋巴细胞增殖的抑制作用。因此，本研究考察了低分子量五味子纯化多糖（SCPP11）在 5-氟尿嘧啶（5-Fu）处理荷瘤小鼠中的抗肿瘤和降低毒性作用。结果表明，当与 5-Fu 联合使用时，SCPP11（口服）表现出显著增强的抗肿瘤活性。此外，当荷瘤小鼠接受 SCPP11 联合 5-Fu 给药时，还观察到免疫功能增强的效果，包括胸腺指数增加和增强血清 IL-2 和 TNF-α分泌。此外，SCPP11 可将 5-Fu 引起的血液和生化参数变化改善至正常水平，并降低 MDA 的形成，增强肝脏中超氧化物歧化酶的活性，以对抗 5-Fu 诱导的自由基损伤。上述结果表明，SCPP11 与 5-Fu 联合使用具有增强的抗肿瘤活性作用，并且 SCPP11 可以减轻 5-Fu 引起的毒性作用。它可以作为化疗药物的一种新的有前途的佐剂。
