A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Vascul Pharmacol. 2019 Jan;112:91-101. doi: 10.1016/j.vph.2018.10.005. Epub 2018 Oct 17.
Vascular endothelial growth factors regulate vascular and lymphatic growth. Dysregulation of VEGF signaling is connected to many pathological states, including hemangiomas, arteriovenous malformations and placental abnormalities. In heart, VEGF gene transfer induces myocardial angiogenesis. Besides vascular and lymphatic endothelial cells, VEGFs affect multiple other cell types. Understanding VEGF biology and its paracrine signaling properties will offer new targets for novel treatments of several diseases.
血管内皮生长因子调节血管和淋巴管的生长。VEGF 信号的失调与许多病理状态有关，包括血管瘤、动静脉畸形和胎盘异常。在心内，VEGF 基因转移可诱导心肌血管生成。除血管和淋巴管内皮细胞外，VEGFs 还影响多种其他细胞类型。了解 VEGF 生物学及其旁分泌信号特性将为几种疾病的新型治疗提供新的靶点。
