Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Dongguan Middle School -SSL School, Dongguan 523808, PR China.
Chemosphere. 2019 Jan;215:524-531. doi: 10.1016/j.chemosphere.2018.10.075. Epub 2018 Oct 15.
The adsorption capacity of three representative pharmaceutical drugs and personal care products (PPCPs) viz. diclofenac sodium (DCF), chlorpromazine hydrochloride (CLF) and amodiaquin dihydrochloride (ADQ), were preliminarily studied using a water-stable Cu(II)-based metal organic framework (MOF) [Cu(BTTA)]·2DMF (1) (HBTTA = 1,4-bis(triazol-1-yl)terephthalic acid). We also investigated the factors influencing the adsorption such as concentration, pH, contact time, temperature and dosages. The results show that the adsorption capacity of 1 for DCF (650 mg g-) from aqueous medium, which is higher in comparison to most of the reported MOFs. While the adsorption of CLF and ADQ are only 67 mg g- and 72 mg g-, respectively. The adsorption isotherm and adsorption kinetics indicated that the adsorption of diclofenac sodium by 1 follows Freundlich model with R value of 0.9902 and pseudo-first-order kinetics with correlation coefficient 0.9939 and K value of 0.0058 min, respectively. Investigations indicate that 1 could become a potential material to adsorb DCF from aqueous medium.
采用水稳定的 Cu(II) 基金属有机骨架（MOF）[Cu（BTTA）]·2DMF（1）（HBTTA=1,4-双（三唑-1-基）对苯二甲酸）初步研究了三种代表性的药物和个人护理产品（PPCPs）即双氯芬酸钠（DCF）、盐酸氯丙嗪（CLF）和盐酸阿莫地喹（ADQ）的吸附能力。我们还研究了影响吸附的因素，如浓度、pH 值、接触时间、温度和剂量。结果表明，1 对水中 DCF（650mg g-）的吸附容量较高，高于大多数报道的 MOFs。而 CLF 和 ADQ 的吸附量分别为 67mg g-和 72mg g-。吸附等温线和吸附动力学表明，1 对双氯芬酸钠的吸附遵循 Freundlich 模型，R 值为 0.9902，准一级动力学，相关系数为 0.9939，K 值为 0.0058 min-1。研究表明，1 可能成为一种从水溶液中吸附 DCF 的潜在材料。
