Liu Yanhua, Xu Zhengyi, Qiao Mingxin, Cai He, Zhu Zhou
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Chem. 2022 Aug 9;10:955993. doi: 10.3389/fchem.2022.955993. eCollection 2022.
Owing to their excellent characteristics, such as large specific surface area, favorable biosafety, and versatile application, nanomaterials have attracted significant attention in biomedical applications. Among them, metal-based nanomaterials containing various metal elements exhibit significant bone tissue regeneration potential, unique antibacterial properties, and advanced drug delivery functions, thus becoming crucial development platforms for bone tissue engineering and drug therapy for orthopedic diseases. Herein, metal-based drug-loaded nanomaterial platforms are classified and introduced, and the achievable drug-loading methods are comprehensively generalized. Furthermore, their applications in bone tissue engineering, osteoarthritis, orthopedic implant infection, bone tumor, and joint lubrication are reviewed in detail. Finally, the merits and demerits of the current metal-based drug-loaded nanomaterial platforms are critically discussed, and the challenges faced to realize their future applications are summarized.
由于具有诸如大比表面积、良好的生物安全性和广泛的应用等优异特性，纳米材料在生物医学应用中引起了广泛关注。其中，含有各种金属元素的金属基纳米材料展现出显著的骨组织再生潜力、独特的抗菌性能和先进的药物递送功能，从而成为骨组织工程和骨科疾病药物治疗的关键发展平台。在此，对金属基载药纳米材料平台进行分类介绍，并全面归纳可实现的载药方法。此外，详细综述了它们在骨组织工程、骨关节炎、骨科植入物感染、骨肿瘤和关节润滑方面的应用。最后，批判性地讨论了当前金属基载药纳米材料平台的优缺点，并总结了实现其未来应用所面临的挑战。
