Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Department of Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Nanomedicine. 2019 Jan;15(1):274-284. doi: 10.1016/j.nano.2018.10.002. Epub 2018 Oct 18.
A woven nanotextile implant was developed and optimized for long-term continuous drug delivery for potential oncological applications. Electrospun polydioxanone (PDS) nanoyarns, which are twisted bundles of PDS nanofibres, were loaded with paclitaxel (PTX) and woven into nanotextiles of different packing densities. A mechanistic modeling of in vitro drug release proved that a combination of diffusion and matrix degradation controlled the slow PTX-release from a nanoyarn, emphasizing the role of nanostructure in modulating release kinetics. Woven nanotextiles, through variations in its packing density and thereby architecture, demonstrated tuneable PTX-release. In vivo PTX-release, pharmacokinetics and biodistribution were evaluated in healthy BALB/c mice by suturing the nanotextile to peritoneal wall. The slow and metronomic PTX-release for 60 days from the loosely woven implant was extremely effective in enhancing its residence in peritoneum, in contrast to intraperitoneal injections. Such an implantable matrix offers a novel platform for therapy of solid tumors over prolonged durations.
一种编织纳米纤维植入物被开发和优化，用于潜在的肿瘤学应用的长期连续药物输送。电纺聚二恶烷酮（PDS）纳米纤维的扭结束被负载紫杉醇（PTX）并编织成不同密度的纳米纤维织物。体外药物释放的机制模型证明，扩散和基质降解的结合控制了从纳米纤维中缓慢释放的 PTX，强调了纳米结构在调节释放动力学中的作用。通过改变其包装密度和结构，编织纳米纤维表现出可调节的 PTX 释放。通过将纳米纤维缝合到腹膜壁上，在健康的 BALB/c 小鼠中评估了体内 PTX 释放、药代动力学和生物分布。与腹腔内注射相比，从疏松编织植入物中缓慢和恒速释放 60 天的 PTX 非常有效地延长了其在腹膜中的停留时间。这种可植入基质为长期治疗实体瘤提供了一种新的治疗平台。
