ACS Appl Mater Interfaces. 2018 Jun 13;10(23):19449-19458. doi: 10.1021/acsami.8b05096. Epub 2018 Jun 4.
This study investigates the unique properties, fabrication technique, and vascular applications of woven nanotextiles made from low-strength nanoyarns, which are bundles of thousands of nanofibers. An innovative robotic system was developed to meticulously interweave nanoyarns in longitudinal and transverse directions, resulting in a flexible, but strong woven product. This is the only technique for producing seamless nanotextiles in tubular form from nanofibers. The porosity and the mechanical properties of nanotextiles could be substantially tuned by altering the number of nanoyarns per unit area. Investigations of the physical and biological properties of the woven nanotextile revealed remarkable and fundamental differences from its nonwoven nanofibrous form and conventional textiles. This enhancement in the material property was attributed to the multitude of hierarchically arranged nanofibers in the woven nanotextiles. This patterned woven nanotextile architecture leads to a superhydrophilic behavior in an otherwise hydrophobic material, which in turn contributed to enhanced protein adsorption and consequent cell attachment and spreading. Short-term in vivo testing was performed, which proved that the nanotextile conduit was robust, suturable, kink proof, and nonthrombogenic and could act as an efficient embolizer when deployed into an artery.
本研究探讨了由数千根纳米纤维组成的低强度纳米纱线制成的编织纳米纺织品的独特性质、制造技术及其在血管中的应用。开发了一种创新的机器人系统，可精细地将纳米纱线纵横交错编织，从而制成柔软但坚固的编织产品。这是唯一可从纳米纤维制造管状无缝纳米纺织品的技术。通过改变单位面积内的纳米纱线数量，可以显著调整纳米纺织品的孔隙率和机械性能。对编织纳米纺织品的物理和生物性能的研究表明，与非织造纳米纤维形式和传统纺织品相比，其具有显著的根本差异。这种材料性能的增强归因于编织纳米纺织品中大量分层排列的纳米纤维。这种图案化的编织纳米纺织品结构使原本疏水的材料具有超亲水性能，从而促进了蛋白质吸附以及随后的细胞附着和扩散。进行了短期体内测试，证明纳米纺织品导管坚固、可缝合、不易扭结、无血栓形成，并且当部署到动脉中时可以作为有效的栓塞剂。
