定量感觉测试对奥沙利铂所致神经病变的管理有帮助吗？一项为期两年的临床研究。

Is quantitative sensory testing helpful in the management of oxaliplatin neuropathy? a two-year clinical study.

作者信息

Delmotte J B, Beaussier H, Auzeil N, Massicot F, Laprévote O, Raymond E, Coudoré F

机构信息

Clinical Research Center, Paris Saint Joseph Hospital, 185 rue Raymond Losserand, Paris, France.

出版信息

Cancer Treat Res Commun. 2018;17:31-36. doi: 10.1016/j.ctarc.2018.10.002. Epub 2018 Oct 10.

DOI:10.1016/j.ctarc.2018.10.002

PMID:30343217

Abstract

PURPOSE

To better understand how quantitative sensory testing could help the clinician in the management of oxaliplatin-induced peripheral neuropathy in terms of earlier and more reliable detection, we conducted a two-year prospective study.

METHODS

Thermal sensory assessment, tactile sensory assessment, neuropathic pain assessment and adverse events gradation (NCI-CTC) were performed during treatment and 6 months after treatment completion.

RESULTS

35 patients were enrolled and followed-up during one year. Cold and Warm Detection Thresholds were higher 6 months after treatment completion than at enrollment. Mechanical detection thresholds didn't change significantly. Neurotoxicity was mostly grade-1, only 18% grade-2 and no grade-3. Grade-2 patients received lower oxaliplatin cumulative dose than grade-1, which reveals effective dose adaptation and grade-2 patients were more likely to develop painful neuropathy.

CONCLUSION

Thermal thresholds impairment emerges too late to help the clinician in the prophylaxis of neuropathy. Management of OXA-treatment based on NCI-CTC, as currently recommended, remains the best way to detect neuropathy and ensure treatment adaptation.

摘要