AKR 胸腺癌细胞系的体外建立及某些特性

In vitro establishment and some properties of AKR thymoma cell lines.

作者信息

Riesenfeld I, Tufveson G, Alm G V

出版信息

Acta Pathol Microbiol Scand A. 1977 Sep;85(5):739-44. doi: 10.1111/j.1699-0463.1977.tb00466.x.

DOI:10.1111/j.1699-0463.1977.tb00466.x

Abstract

Lymphoid cell lines could easily be directly established in vitro from spontaneous thymomas of aged AKR mice. The established lines all carried the Thy-1.1 antigenic marker of T lymphocytes. They differed markedly, however, from one another in several respects. Thus, they showed high or low quantity of Thy-1.1 antigens per cell, high or low sensitivity to cortisone and thymidine, as well as differing morphology and growth rate. The observed heterogeneity suggests that such AKR thymoma cell lines may provide a valuable tool to study T lymphocyte properties and the biology of the AKR thymoma, in particular non-immune and immune mechanisms influencing thymoma cell growth.

摘要

可以很容易地从老年AKR小鼠的自发性胸腺瘤中直接在体外建立淋巴细胞系。所建立的细胞系都带有T淋巴细胞的Thy-1.1抗原标记。然而，它们在几个方面彼此有显著差异。因此，它们显示出每个细胞中Thy-1.1抗原的数量有高有低，对可的松和胸腺嘧啶核苷的敏感性有高有低，以及形态和生长速率不同。观察到的异质性表明，这种AKR胸腺瘤细胞系可能为研究T淋巴细胞特性和AKR胸腺瘤的生物学，特别是影响胸腺瘤细胞生长的非免疫和免疫机制提供一个有价值的工具。