胸腺瘤细胞免疫球蛋白对体外T细胞依赖性免疫反应的抑制作用。
Inhibition of a T-cell-dependent immune response in vitro by thymoma cell immunoglobulin.
作者信息
Stocker J W, Marchalonis J J, Harris A W
出版信息
J Exp Med. 1974 Mar 1;139(3):785-90. doi: 10.1084/jem.139.3.785.
Abstract
Concentrated medium obtained from cultures of a continuous thymus-derived mouse lymphoma cell line (WEHI-22.1) was found to inhibit a T-cell-dependent (antidonkey red blood cell), but not a T-cell-independent (anti-DNP) immune response in vitro. Passage of such a concentrate through an anti-mouse Ig immunoadsorbent column removed its inhibitory activity. It is suggested that the tumor cell Ig can compete with specific normal T-cell Ig in its collaborative function in immune responses. A similar mechanism may account for anergy associated with some human lymphoid neoplasms.
摘要
从连续传代的源自胸腺的小鼠淋巴瘤细胞系（WEHI-22.1）培养物中获得的浓缩物，在体外可抑制依赖T细胞的（抗驴红细胞）免疫反应，但不能抑制不依赖T细胞的（抗二硝基苯酚）免疫反应。将这种浓缩物通过抗小鼠Ig免疫吸附柱后，其抑制活性消失。这表明肿瘤细胞Ig在免疫反应的协同功能中可与正常特异性T细胞Ig竞争。类似的机制可能解释了与某些人类淋巴肿瘤相关的无反应性。
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