Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, UK.
J Neural Transm (Vienna). 2018 Dec;125(12):1819-1827. doi: 10.1007/s00702-018-1945-6. Epub 2018 Oct 20.
People with Parkinson's disease (PD) have a deficit of facial expression. Previous studies indicate that hemispheric dominance for emotional processing can give rise to an asymmetric pattern of facial expression of emotion. In this study, we aimed to evaluate possible asymmetry in facial emotion expressivity in PD. Twenty PD patients and twenty healthy controls were video-recorded while posing the 6 basic emotions. The most expressive pictures were derived from the videos and chimeric faces were created. Nine healthy raters were asked to judge which of the two chimeras looked more expressive. Chosen responses, reaction times and confidence levels were the main outcome measures. We evaluated possible differences in these measures within each group and between groups (PD, healthy controls). We assessed possible correlations between a global facial laterality index (pooling all emotions together) as well as facial laterality indexes for each emotion and the body laterality index, accounting for the predominant side of limb bradykinesia in patients. There was no difference in outcome measures when evaluating the two hemifaces within PD patients and healthy controls or between the two groups (all Ps > 0.05). In PD patients there was a correlation between the global facial laterality index and the body laterality index (R = - 0.39, P = 0.01), suggesting that the most expressive hemiface corresponded to the less affected body side. The results of our study do not support the hypothesis of hemisphere predominance in regulating facial emotion expressions and provides novel information on altered facial emotion expression in PD.
帕金森病（PD）患者的面部表情存在缺陷。先前的研究表明，情绪处理的半球优势可能导致情绪面部表情的不对称模式。在这项研究中，我们旨在评估 PD 患者面部表情表达可能存在的不对称性。我们对 20 名 PD 患者和 20 名健康对照者进行了视频录制，让他们摆出 6 种基本情绪。从视频中提取出最具表现力的图片，并创建了混合脸。9 名健康评分者被要求判断哪张混合脸看起来更有表现力。选择的反应、反应时间和置信度是主要的测量结果。我们评估了这些措施在每组内以及组间（PD、健康对照组）的差异。我们评估了全局面部侧化指数（将所有情绪结合在一起）以及每个情绪的面部侧化指数与肢体运动迟缓的主要侧体侧化指数之间的可能相关性。在评估 PD 患者和健康对照组的两个半脸或两组之间的结果测量时，没有差异（所有 P 值均>0.05）。在 PD 患者中，全局面部侧化指数与身体侧化指数之间存在相关性（R= - 0.39，P= 0.01），这表明最具表现力的半脸对应于受影响较小的身体侧。我们的研究结果不支持调节面部表情表达的半球优势假说，并为 PD 中改变的面部表情表达提供了新的信息。
