肩周炎与高胆固醇血症：载脂蛋白A1基因多态性在病因及严重程度中的作用

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity.

作者信息

Gumina S, Candela V, Castagna A, Carnovale M, Passaretti D, Venditto T, Giannicola G, Villani C

机构信息

Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Polo Pontino (ICOT), Latina, Italy.

Department of Orthopaedics and Traumatology, Humanitas Clinic, Rozzano, Milan, Italy.

出版信息

Musculoskelet Surg. 2018 Oct;102(Suppl 1):35-40. doi: 10.1007/s12306-018-0557-5. Epub 2018 Oct 20.

DOI:10.1007/s12306-018-0557-5

PMID:30343478

Abstract

PURPOSE

Relationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC.

METHODS

Peripheral blood samples of 27 patients [7M; 20F, mean age 54.81 (41-65)] with AC and hypercholesterolemia were submitted to polymerase chain reaction in order to evaluate the Apo-A1-G75A-polymorphism. Genome database was used as control. Two categories were obtained according to AC severity: type I (active forward flexion ≥ 100°) and type II (< 100°). Data were submitted to statistics.

RESULTS

The prevalence of Apo-A1-G75A-polymorphism in the studied group and in the control group was 22.2% (10AG; 1AA; 16GG) and 19% (OR 1.22, IC 0.59-2.53, p > 0.05), respectively. Patients with type I and II capsulitis were 11 [flexion 148.0° (range 100°-165°)] and 16 [flexion 82.5° (range 50°-95°)], respectively. The prevalence of Apo-A1-G75A in type I was 18.1% (2AG; 9GG) and in type II was 56.3% (8GA; 1AA; 7GG), respectively (RR 1.87, IC 1.005-3.482, p < 0.05).

CONCLUSIONS

Apo-A1-G75A-polymorphism is not necessary for the genesis, but it is a risk factor for severity of AC.

LEVEL OF EVIDENCE

III.

摘要

目的

已知肩周炎（AC）与高胆固醇血症之间存在关联。连接环节可能由高密度脂蛋白（HDL）与转化生长因子β（TGF-β）之间的相关性来体现：正常情况下，HDL刺激TGF-β表达；后者参与纤维组织的形成。我们评估与HDL功能增强相关的载脂蛋白A1-G75A多态性的存在是否可能是AC发生和严重程度的危险因素。

方法

对27例患有AC和高胆固醇血症的患者[7名男性；20名女性，平均年龄54.81岁（41 - 65岁）]的外周血样本进行聚合酶链反应，以评估载脂蛋白A1-G75A多态性。以基因组数据库作为对照。根据AC严重程度分为两类：I型（主动前屈≥100°）和II型（<100°）。数据进行统计学分析。

结果

研究组和对照组中载脂蛋白A1-G75A多态性的患病率分别为22.2%（10AG；1AA；16GG）和19%（比值比1.22，可信区间0.59 - 2.53，p>0.05）。I型和II型肩周炎患者分别为11例[前屈148.0°（范围100° - 165°）]和16例[前屈82.5°（范围50° - 95°）]。I型中载脂蛋白A1-G75A的患病率为18.1%（2AG；9GG），II型中为56.3%（8GA；1AA；7GG），分别（相对危险度1.87，可信区间1.005 - 3.482，p<0.05）。