Peracchi M, Toschi V, Bamonti-Catena F, Lombardi L, Bareggi B, Cortelezzi A, Colombi M, Maiolo A T, Polli E E
Blood. 1987 Jun;69(6):1613-6.
To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients' response to treatment.
为验证细胞外环核苷酸测定作为肿瘤标志物的临床实用性，我们检测了70名正常受试者和173名处于疾病不同阶段的急性白血病患者血浆中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的水平。白血病患者和正常受试者的血浆cAMP平均水平相似，不过在疾病活动期、初次诊断或复发的48例患者中，cAMP值低于正常范围，且这些患者中的大多数对化疗无反应。未经治疗的患者血浆cGMP水平显著升高，所有达到完全缓解的患者其水平恢复正常，而复发患者的cGMP水平迅速升至治疗前值，这表明检测cGMP水平可能有助于监测患者对治疗的反应。
