Naito E, Shimoji K, Endoh H, Ichikawa T, Hashiba M
Stroke. 1983 May-Jun;14(3):380-2. doi: 10.1161/01.str.14.3.380.
Concentrations of cyclic AMP and cyclic GMP in arterial and internal jugular venous (IJV) blood were determined at the resting wakeful state in thirty surgical patients without neurological deficits. The levels of cyclic AMP in artery and IJV were 32.1 +/- 3.0 and 40.0 +/- 4.1 pmol/ml (means +/- standard errors), respectively, while those of cyclic GMP in artery and IJV were 12.2 +/- 2.7 and 14.4 +/- 3.0 pmol/ml, respectively. Concentrations of both cyclic nucleotides in IJV were significantly higher (P less than 0.001) than those in artery. IJV-arterial differences for cAMP and cGMP were 7.9 +/- 1.7 and 2.1 +/- 0.5 pmol/ml, respectively. The results indicate that both cyclic nucleotides are constantly produced and released from the normal human brain.
在30名无神经功能缺损的外科手术患者处于静息清醒状态时，测定其动脉血和颈内静脉血中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的浓度。动脉血和颈内静脉血中cAMP的水平分别为32.1±3.0和40.0±4.1皮摩尔/毫升（均值±标准误），而动脉血和颈内静脉血中cGMP的水平分别为12.2±2.7和14.4±3.0皮摩尔/毫升。颈内静脉血中两种环核苷酸的浓度均显著高于动脉血（P<0.001）。cAMP和cGMP的颈内静脉血-动脉血差值分别为7.9±1.7和2.1±0.5皮摩尔/毫升。结果表明，这两种环核苷酸均持续由正常人脑产生并释放。
