Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
School of Population and Public Health, University of British Columbia, Vancouver, Canada; British Columbia Centre for Disease Control, Vancouver, Canada.
Int J Drug Policy. 2018 Nov;61:52-58. doi: 10.1016/j.drugpo.2018.09.009. Epub 2018 Oct 18.
The overdose epidemic has been exacerbated by a dramatic increase in deaths involving illicitly manufactured fentanyl (IMF). Drug checking is a novel strategy to identify IMF in illicit drugs. We examined the uptake and acceptability of rapid fentanyl test strips among young adults.
From May to September 2017, we recruited 93 young adults in Rhode Island who reported injecting drugs or using heroin, cocaine, or illicitly obtained prescription pills in the past 30 days. Participants were asked to test either their urine after drug use (post-consumption) or a drug sample prior to use (pre-consumption) using rapid fentanyl test strips. After a questionnaire and a brief training, participants received ten strips for their personal use and were asked to return for a one-month follow-up visit, which assessed the uptake and acceptability of the rapid strips tests and the behavioral outcomes associated with receipt of a positive test.
Of the 81 (87%) participants who returned for follow-up and who had complete data, the mean age was 27, 45 (56%) were male, and 37 (46%) were non-white. A total of 62 participants (77%) reported using at least one test strip. Of these, 31 (50%) received at least one positive result. A positive result was associated with older age, homelessness, heroin use, injection drug use, ever witnessing an overdose, and concern about overdose or drugs being laced with fentanyl (all p < 0.05). Receiving a positive result was significantly associated with reporting a positive change in overdose risk behavior between baseline and follow-up (p ≤ 0.01). Among all participants, 79 (98%) reported confidence in their ability to use the test strips and 77 (95%) wanted to use them in the future.
Young adults reported high uptake and acceptability of fentanyl test strips to detect IMF in illicit drugs.
非法制造的芬太尼(IMF)导致的死亡人数急剧增加,使过量用药问题恶化。药物检测是一种识别非法药物中 IMF 的新策略。我们研究了快速芬太尼检测条在年轻成年人中的采用和可接受性。
2017 年 5 月至 9 月,我们在罗德岛招募了 93 名报告在过去 30 天内使用过注射药物或使用过海洛因、可卡因或非法获得的处方药丸的年轻成年人。参与者被要求使用快速芬太尼检测条检测他们在使用药物后的尿液(使用后)或在使用前的药物样本(使用前)。在问卷调查和简短培训后,参与者获得了十条检测条供个人使用,并被要求在一个月后进行随访,评估快速检测条的采用和可接受性,以及与收到阳性检测结果相关的行为结果。
在 81 名(87%)返回进行随访且数据完整的参与者中,平均年龄为 27 岁,45 名(56%)为男性,37 名(46%)为非白人。共有 62 名参与者(77%)报告至少使用了一条检测条。其中,31 名(50%)收到了至少一个阳性结果。阳性结果与年龄较大、无家可归、使用海洛因、使用注射药物、曾目睹过过量用药以及担心过量用药或药物被芬太尼掺杂(均 p<0.05)有关。收到阳性结果与报告在基线和随访之间过量用药风险行为发生阳性变化显著相关(p≤0.01)。在所有参与者中,79 名(98%)报告对自己使用检测条的能力有信心,77 名(95%)希望将来使用它们。
年轻成年人报告了对快速芬太尼检测条检测非法药物中 IMF 的高采用和可接受性。