Ferreira Tatiana H, Mans Christoph
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Vet Anaesth Analg. 2019 Jan;46(1):126-134. doi: 10.1016/j.vaa.2018.09.001. Epub 2018 Sep 19.
To assess the feasibility, success rate, onset, duration and extent of motor/sensory block following intrathecal injection of lidocaine in bearded dragons (Pogona vitticeps).
Prospective experimental study.
A group of eight adult bearded dragons (0.333 ± 0.048 kg).
The animals were sedated with alfaxalone (15 mg kg) subcutaneously. Neuraxial injections were performed with 1% lidocaine (2 mg kg) or 0.9% sodium chloride (0.2 mL kg) in all animals with a 7 day interval. If the initial injection did not result in motor block of the pelvic limbs within 10 minutes, a second injection was performed at the same dose. Measurements consisted of bilateral mechanical stimulation of limbs; 25%, 50%, and 75% of the trunk's length; and cloacal tone. Animals were monitored for any untoward side effects by monitoring heart rate (HR), respiratory rate, righting reflex and head position.
Success rate following the first injection of lidocaine was 50% (four out of eight animals) and increased to 75% (six out of eight animals) following a second injection. Onset of motor/sensory block occurred within 5 minutes in all successful injections. Duration and extent were variable, with most bearded dragons presenting motor/sensory block of cloaca and pelvic limbs (six out of six) and 25% of the trunk (five out of six) with mean ± standard deviation (range) duration of 49 ± 28 (25-100), 48 ± 25 (25-90) and 40 ± 14 (25-50) minutes, respectively. Confirmation of intrathecal injection by aspiration of cerebrospinal fluid was not possible. Neuraxial lidocaine significantly increased depth and duration of sedation, with a transient increase in HR, compared with saline.
Neuraxial lidocaine is a feasible technique with moderate success rate and low risk of complication in bearded dragons. This technique has potential for improving the management of anesthesia in this species.
评估在髯狮蜥（鬃狮蜥）鞘内注射利多卡因后运动/感觉阻滞的可行性、成功率、起效时间、持续时间和范围。
前瞻性实验研究。
一组八只成年髯狮蜥（0.333±0.048千克）。
动物经皮下注射阿法沙龙（15毫克/千克）进行镇静。所有动物均以7天的间隔注射1%利多卡因（2毫克/千克）或0.9%氯化钠（0.2毫升/千克）进行神经轴内注射。如果初次注射在10分钟内未导致后肢运动阻滞，则以相同剂量进行第二次注射。测量包括对四肢、躯干长度的25%、50%和75%以及泄殖腔张力进行双侧机械刺激。通过监测心率（HR）、呼吸频率、翻正反射和头部位置来监测动物是否有任何不良副作用。
首次注射利多卡因后的成功率为50%（八只动物中有四只），第二次注射后升至75%（八只动物中有六只）。所有成功注射中运动/感觉阻滞均在5分钟内起效。持续时间和范围各不相同，大多数髯狮蜥出现泄殖腔和后肢的运动/感觉阻滞（六只中有六只）以及躯干25%的运动/感觉阻滞（六只中有五只），平均±标准差（范围）持续时间分别为49±28（25 - 100）、48±25（25 - 90）和40±14（25 - 50）分钟。无法通过抽取脑脊液来确认鞘内注射。与生理盐水相比，神经轴内利多卡因显著增加了镇静深度和持续时间，并使心率短暂升高。
神经轴内利多卡因是一种可行的技术，在髯狮蜥中成功率适中且并发症风险低。该技术有改善该物种麻醉管理的潜力。
