对接受阿法沙龙镇静的鬃狮蜥（鬃狮蜥）肌肉注射利多卡因的镇静和生理效应的评估。

Evaluation of the sedative and physiological effects of intramuscular lidocaine in bearded dragons (Pogona vitticeps) sedated with alfaxalone.

作者信息

Ferreira Tatiana H, Mans Christoph, Di Girolamo Nicola

机构信息

Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

出版信息

Vet Anaesth Analg. 2019 Jul;46(4):496-500. doi: 10.1016/j.vaa.2019.03.003. Epub 2019 Mar 28.

DOI:10.1016/j.vaa.2019.03.003

PMID:31076335

Abstract

OBJECTIVE

To evaluate if intramuscular (IM) lidocaine potentiates the sedative effects of alfaxalone and results in cardiopulmonary changes in sedated bearded dragons.

STUDY DESIGN

Prospective experimental crossover study.

ANIMALS

A group of eight adult bearded dragons (Pogona vitticeps) weighing 334 ± 46 g.

METHODS

Animals were administered alfaxalone (10 mg kg subcutaneously) and 15 minutes later either lidocaine 2% (4 mg kg) or 0.9% sodium chloride (0.2 mL kg) was administered IM in the thoracic limb. The treatments were randomized and separated by 7 days. Sedation was scored based on body position, eye closure, jaw tone, swallowing, pick up response, righting reflex and pelvic limb withdrawal reflex. Heart rate (HR) and respiratory rate (f) were recorded every 5 minutes until recovery from sedation.

RESULTS

Lidocaine had no significant effect on duration or depth of alfaxalone sedation. HR increased significantly for <10 minutes following lidocaine administration by a median (interquartile range) of 33% (28-37%; p = 0.024). No clinically significant effects on f occurred following lidocaine injection.

CONCLUSIONS AND CLINICAL RELEVANCE

Administration of lidocaine 2% (4 mg kg) IM did not potentiate alfaxalone sedation but resulted in a transient clinically relevant increase in HR.

摘要

目的

评估肌肉注射利多卡因是否能增强阿法沙龙的镇静效果，并导致麻醉状态下的鬃狮蜥出现心肺变化。

研究设计

前瞻性实验交叉研究。

动物

一组8只成年鬃狮蜥（鬃狮蜥），体重334±46克。

方法

给动物皮下注射阿法沙龙（10毫克/千克），15分钟后在胸肢肌肉注射2%利多卡因（4毫克/千克）或0.9%氯化钠（0.2毫升/千克）。治疗方法随机分配，间隔7天。根据动物的体位、闭眼情况、颌肌张力、吞咽动作、抓取反应、翻正反射和后肢回缩反射对镇静程度进行评分。每隔5分钟记录心率（HR）和呼吸频率（f），直至从镇静状态恢复。