Ferreira Tatiana H, Mans Christoph, Di Girolamo Nicola
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Vet Anaesth Analg. 2019 Jul;46(4):496-500. doi: 10.1016/j.vaa.2019.03.003. Epub 2019 Mar 28.
To evaluate if intramuscular (IM) lidocaine potentiates the sedative effects of alfaxalone and results in cardiopulmonary changes in sedated bearded dragons.
Prospective experimental crossover study.
A group of eight adult bearded dragons (Pogona vitticeps) weighing 334 ± 46 g.
Animals were administered alfaxalone (10 mg kg subcutaneously) and 15 minutes later either lidocaine 2% (4 mg kg) or 0.9% sodium chloride (0.2 mL kg) was administered IM in the thoracic limb. The treatments were randomized and separated by 7 days. Sedation was scored based on body position, eye closure, jaw tone, swallowing, pick up response, righting reflex and pelvic limb withdrawal reflex. Heart rate (HR) and respiratory rate (f) were recorded every 5 minutes until recovery from sedation.
Lidocaine had no significant effect on duration or depth of alfaxalone sedation. HR increased significantly for <10 minutes following lidocaine administration by a median (interquartile range) of 33% (28-37%; p = 0.024). No clinically significant effects on f occurred following lidocaine injection.
Administration of lidocaine 2% (4 mg kg) IM did not potentiate alfaxalone sedation but resulted in a transient clinically relevant increase in HR.
评估肌肉注射利多卡因是否能增强阿法沙龙的镇静效果，并导致麻醉状态下的鬃狮蜥出现心肺变化。
前瞻性实验交叉研究。
一组8只成年鬃狮蜥（鬃狮蜥），体重334±46克。
给动物皮下注射阿法沙龙（10毫克/千克），15分钟后在胸肢肌肉注射2%利多卡因（4毫克/千克）或0.9%氯化钠（0.2毫升/千克）。治疗方法随机分配，间隔7天。根据动物的体位、闭眼情况、颌肌张力、吞咽动作、抓取反应、翻正反射和后肢回缩反射对镇静程度进行评分。每隔5分钟记录心率（HR）和呼吸频率（f），直至从镇静状态恢复。
利多卡因对阿法沙龙镇静的持续时间或深度没有显著影响。注射利多卡因后，心率在<10分钟内显著增加，中位数（四分位间距）为33%（28 - 37%；p = 0.024）。注射利多卡因后对呼吸频率没有临床显著影响。
肌肉注射2%利多卡因（4毫克/千克）不会增强阿法沙龙的镇静作用，但会导致心率出现短暂的临床相关增加。
