School of Health Sciences, Faculty of Medicine, Department of Obstetrics and Gynaecology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece.
School of Health Sciences, Faculty of Medicine, Department of Morphology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece.
Medicina (Kaunas). 2018 Jul 27;54(4):50. doi: 10.3390/medicina54040050.
Human papilloma virus (HPV) is one of the most prevalent viral sexually transmitted diseases. The ability of HPV to induce malignancy in the anogenital tract and stomato-pharyngeal cavity is well documented. Moreover, HPV infection may also affect reproductive health and fertility. Although, the impact of HPV on female fertility has not been thoroughly studied it has been found also to have an impact on semen parameters. Relative information can be obtained from studies investigating the relationship between HPV and pregnancy success. Furthermore, there is an ongoing debate whether HPV alters the efficacy of assisted reproductive technologies. An association between HPV and assisted reproductive technologies (ART) programs has been reported. Nevertheless, due to conflicting data and the small number of existing studies further research is required. It remains to be clarified whether HPV detection and genotyping could be included in the diagnostic procedures in couples undergoing in vitro fertilization (IVF)/intrauterine insemination (IUI) treatments. Vaccination of both genders against HPV can reduce the prevalence of HPV infection and eliminate its implications on human fertility. The aim of the present mini-review is to reiterate the association between HPV and human fertility through a systematic literature review.
人乳头瘤病毒（HPV）是最常见的性传播病毒之一。HPV 在肛门生殖器和口腔咽部诱发恶性肿瘤的能力已有充分记录。此外，HPV 感染也可能影响生殖健康和生育能力。尽管 HPV 对女性生育能力的影响尚未得到彻底研究，但也发现它会影响精液参数。可以从研究 HPV 与妊娠成功率之间关系的研究中获得相关信息。此外，关于 HPV 是否改变辅助生殖技术的疗效仍存在争议。已经报道了 HPV 与辅助生殖技术（ART）方案之间的关联。然而，由于数据冲突和现有研究数量较少，需要进一步研究。HPV 的检测和基因分型是否可以纳入接受体外受精（IVF）/宫腔内人工授精（IUI）治疗的夫妇的诊断程序仍有待澄清。对两性进行 HPV 疫苗接种可以降低 HPV 感染的流行率，并消除其对人类生育能力的影响。本综述的目的是通过系统的文献回顾重申 HPV 与人类生育能力之间的关联。
